TRPM5 Antibody

說明書

中文名稱：

TRPM5兔多克隆抗體
貨號：

CSB-PA025087GA01HU
規(guī)格：

￥3,900
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

Q9NZQ8
基因名：

TRPM5
別名：

9430099A16Rik antibody; Long transient receptor potential channel 5 antibody; LTrpC-5 antibody; LTrpC5 antibody; MLSN1 and TRP related gene 1 antibody; MLSN1 and TRP related gene 1 protein antibody; MLSN1 and TRP-related antibody; MLSN1- and TRP-related gene 1 protein antibody; MTR1 antibody; Novel protein similar to vertebrate transient receptor potential cation channel, subfamily M, member 5 antibody; Transient receptor potential cation channel subfamily M member 5 antibody; Transient receptor potential cation channel, subfamily M, member 5 antibody; Trpm5 antibody; TRPM5 transient receptor potential cation channel, subfamily M, member 5 antibody; TRPM5_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human TRPM5
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.
基因功能參考文獻：
1. genetic association studies in populations in Northern Europe, Maghreb, and Sri Lanka: Data suggest that SNPs in TAS2R50 (rs1376251), TRPM5 (rs800345), and TAS2R16 (rs860170) are associated with cultural food preferences; TAS2R16 (rs860170) strongly differentiates populations and is associated to salicin bitterness perception. (TAS2R = taste receptor type 2) PMID: 28366770
2. Our results suggest roles of TRPM3 and TRPM5 gene variants in the susceptibility to or clinical expression of Systemic sclerosis PMID: 26546534
3. The PKC-dependent effect of GLP-1 on membrane potential and electrical activity was mediated by activation of Na(+)-permeable TRPM4 and TRPM5 channels by mobilization of intracellular Ca(2+) from thapsigargin-sensitive Ca(2+) stores PMID: 26571400
4. In a Turkish population, genetic polymorphism in TRPM5 genes modify individual susceptibility to metabolic syndrome. PMID: 25967713
5. TRPM5-mediated Na(+) entry to promote Ca(2+) uptake via an NCX to trigger MUC5AC secretion PMID: 23741618
6. TrpM5 expression was similar throughout the olfactory glomeruli. PMID: 24288162
7. The TRPM5 gene rs34551253 (Ala456Thr) polymorphism may be associated with increased risk of developing primary open angle glaucoma in the Turkish population. PMID: 24019741
8. AZIN1 rs2679757 and TRPM5 rs886277 are associated with the risk of HBV-related liver cirrhosis in Chinese. PMID: 23844940
9. extracellular Zn(2+) inhibits TRPM5 channels, and the residues in the outer pore loop of TRPM5 are critically involved in the inhibition. PMID: 23884414
10. common TRPM5 variants are likely to be associated with prediabetic phenotypes; and this may in turn contribute to the development of type 2 diabetes mellitus PMID: 21489577
11. results suggest TRPM5 may play a role in upregulating endogenous expression of TRPA1, that TRPA1 activation may be an additional trigger for co-expressed calcium-dependent ion channels such as TRPM5, and that TRPM5 may amplify responses to TRPA1 ligands PMID: 21133676
12. TRPM5 gene is imprinted, with preferential expression from the paternal allele. PMID: 10607831
13. TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i PMID: 14634208
14. regulation of TRPM5 by Ca2+ mediates sensory activation in the taste system PMID: 14657398
15. data show that extracellular acidification acts through specific residues on transient receptor potential cation channel, subfamily M(TRPM5) to block conduction through two distinct but related mechanisms PMID: 15731110
16. understanding the structural basis for TRPM5 function will ultimately allow the design of pharmaceuticals to enhance or interfere with taste sensations--{REVIEW} PMID: 17217064
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

Transient receptor (TC 1.A.4) family, LTrpC subfamily, TRPM5 sub-subfamily
組織特異性：

Strongly expressed in fetal brain, liver and kidney, and in adult prostate, testis, ovary, colon and peripheral blood leukocytes. Also expressed in a large proportion of Wilms' tumors and rhabdomyosarcomas. In monochromosomal cell lines shows exclusive pa
數(shù)據(jù)庫鏈接：

HGNC: 14323

OMIM: 604600

KEGG: hsa:29850

STRING: 9606.ENSP00000155858

UniGene: Hs.272287

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