TRPC7 Antibody

說明書

中文名稱：

TRPC7兔多克隆抗體
貨號：

CSB-PA954426
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA954426(TRPC7 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA954426(TRPC7 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9HCX4
基因名：

TRPC7
別名：

Capacitative calcium channel TRPC7 antibody; cation channel; subfamily C; member 7 antibody; hTRP7 antibody; KNP3 antibody; Likley ortholog of mouse transient receptor potential cation channel subfamily C member 7 antibody; mTRP7 antibody; Putative capacitative calcium channel antibody; Short transient receptor potential channel 7 antibody; Transient receptor potential cation channel subfamily C member 7 antibody; transient receptor potential-related channel 7; a novel putative Ca2+ channel protein antibody; Transient receptor protein 7 antibody; TRP 7 antibody; TRP-7 antibody; TRP7 protein antibody; TRPC 7 antibody; TrpC7 antibody; Trpc7 transient receptor potential cation channel; subfamily C; member 7 antibody; TRPC7_HUMAN antibody; TRPM2 antibody; Trrp8 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Fusion protein of Human TRPC7
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG). May also be activated by intracellular calcium store depletion.
基因功能參考文獻：
1. A fundamental role for PI(4,5)P2 was identified in the regulation of TRPC7 and TRPC6. PMID: 24470487
2. Phosphorylation of transient receptor potential cation channel subfamily C member 7 significantly suppressed carbachol-induced calcium influx and CREB phosphorylation. PMID: 21402151
3. Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx PMID: 11805119
4. can be activated by both receptor- and store-operated modes in the same cell. PMID: 15342342
5. endogenous TRPC1, TRPC3, and TRPC7 participate in forming heteromeric store-operated channels, whereas TRPC3 and TRPC7 can also participate in forming heteromeric receptor-operated channels. PMID: 15972814
6. in B-lymphocytes, TRPC7 appears to participate in the formation of ion channels that could be activated by phospholipase C-linked receptors PMID: 16123040
7. activation of both muscarinic and purinergic receptors via a common DAG-dependent link opens Ca(2+)-permeable TRPC7 channels PMID: 16741513
8. the physiological importance of TRPC7 in the native environment remains elusive, TRPC7 would play important roles in Ca2+ signaling pathway--{REVIEW} PMID: 17217055
9. Expression and activity of TRPM7 is modulated by extracellular Mg2+ and Ca2+ availability, indicating that TRPM7 channels are involved in intracellular ion homeostasis and proliferation of osteoblasts. PMID: 18021175
10. heteromeric cation channels comprised of the TRPP2 mutant and the TRPC3 or TRPC7 protein induce enhanced receptor-activated Ca(2+) influx that may lead to dysregulated cell growth in ADPKD PMID: 19812035
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亞細胞定位：

Cell membrane; Multi-pass membrane protein. Nucleus envelope.
蛋白家族：

Transient receptor (TC 1.A.4) family, STrpC subfamily, TRPC7 sub-subfamily
數據庫鏈接：

HGNC: 20754

KEGG: hsa:57113

STRING: 9606.ENSP00000426070

UniGene: Hs.591263

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