TRMT5 Antibody

說明書

產品詳情

Uniprot No.：

Q32P41
基因名：

TRMT5
別名：

TRMT5 antibody; KIAA1393 antibody; TRM5 antibody; tRNA antibody; guanine(37)-N1)-methyltransferase antibody; EC 2.1.1.228 antibody; M1G-methyltransferase antibody; tRNA [GM37] methyltransferase antibody; tRNA methyltransferase 5 homolog antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human TRMT5
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Involved in mitochondrial tRNA methylation. Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
基因功能參考文獻：
1. TRMT5 mutations cause a defect in post-transcriptional modification of mitochondrial tRNA associated with multiple respiratory-chain deficiencies. PMID: 26189817
2. Conservation of structure and mechanism by Trm5 enzymes PMID: 23887145
3. comparison of human TRM5 and E Coli TrmD activities, requirements for optimal activity, and tRNA methylation sites PMID: 15248782
相關疾病：

Combined oxidative phosphorylation deficiency 26 (COXPD26)
亞細胞定位：

Mitochondrion matrix. Nucleus. Cytoplasm.
蛋白家族：

Class I-like SAM-binding methyltransferase superfamily, TRM5/TYW2 family
數據庫鏈接：

HGNC: 23141

OMIM: 611023

KEGG: hsa:57570

STRING: 9606.ENSP00000261249

UniGene: Hs.380159

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