TRIP6 Antibody
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中文名稱：TRIP6兔多克隆抗體
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貨號：CSB-PA024528GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：MGC10556 antibody; MGC10558 antibody; MGC29959 antibody; MGC3837 antibody; MGC4423 antibody; OIP-1 antibody; OIP1 antibody; OPA interacting protein 1 antibody; OPA-interacting protein 1 antibody; Thyroid hormone receptor interactor 6 antibody; Thyroid receptor interacting protein 6 antibody; Thyroid receptor-interacting protein 6 antibody; TR-interacting protein 6 antibody; TRIP-6 antibody; Trip6 antibody; TRIP6_HUMAN antibody; TRIP6i2 antibody; ZRP 1 antibody; ZRP-1 antibody; Zyxin-related protein 1 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human TRIP6
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IF
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.
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基因功能參考文獻：
- Taken together, these findings showed that TRIP6 plays an important role in promoting HCC cells proliferation and may serve as a novel prognostic biomarker and therapeutic target in HCC. PMID: 29080747
- TRIP6 promotes tumor proliferation and reverses cell adhesion-mediated drug resistance via regulating nuclear p27(Kip1) expression in non-Hodgkin's lymphoma PMID: 26298725
- the Trip6-GRIP1-myosin VI interaction and its regulation on F-actin network play a significant role in dendritic morphogenesis PMID: 25673849
- TRIP6 acts, in contrast to Zyxin, as an oncogene that partially accounts for the autonomous migratory, invasive and proliferative properties of Ewing's sarcoma cells. PMID: 24033704
- TRIP6 overexpression promotes migration, invasion, and clonogenicity of Ewing's sarcoma cells PMID: 24033704
- TRIP6 is involved in the regulation of nasopharyngeal carcinoma cell motility, and phosphorylation of tyrosine 55 residue plays an important regulatory role for this event PMID: 23576104
- TRIP6 also promotes serum-induced reduction of nuclear p27(KIP1) expression levels. PMID: 23339869
- High TRIP6 expression is associated with malignant pleural mesothelioma. PMID: 23313295
- TRIP6 is engaged in cell proliferation, differentiation, transcription regulation and contributes to genome stability. [Review] PMID: 22054418
- TRIP6 is a nucleocytoplasmatic shuttle protein essential for the coordination of focal adhesion dynamics and transcriptional responses in lysophosphosphatidic (LPA) and NF-kappaB signaling. PMID: 22054418
- TRIP6 is an adaptor protein that regulates cell motility, antiapoptotic signaling and transcriptional activity. (Review) PMID: 21689746
- TRIP6 promotes Fas-mediated cell migration in apoptosis-resistant glioma cells. This effect is regulated via the Src-dependent phosphorylation of TRIP6 at Tyr-55. PMID: 20876301
- the OIP-1 c-peptide is the functional domain of OIP-1 PMID: 11771657
- TRIP6 functions at a point of convergence between the activated LPA(2) receptor and downstream signals involved in cell adhesion and migration PMID: 14688263
- ZRP-1 has a role in endoglin regulation of cytoskeletal organization PMID: 15148318
- The data establish a physical and functional association between TRIP6 and RIP2, and suggest that RIP2's involvement in multiple NF-kappaB and ERK activation pathways is mediated through TRIP6. PMID: 15657077
- Binding of LPP and TRIP6 to Scrib links Scrib to a communication pathway between cell-cell contacts and the nucleus, and implicates these zyxin family members in Scrib-associated functions. PMID: 16137684
- The TRIP6 knock-down led to an increased number of longer stress fibers and to the induction of locomotive phenotype in carcinoma cells. PMID: 16240724
- AMPK phosphorylated TRIP6 in vitro at the N-terminus and the transcriptional co-activator properties of TRIP6 were enhanced by AMPK action. PMID: 16624523
- ZRP-1 plays a crucial role in coupling the cell-matrix/cell-cell-contact signals with Rho GTPase-mediated actin remodeling by localizing at cell-matrix and cell-cell contact sites. PMID: 17652164
- OIP-1 inhibits measles virus nucleocapsid protein induced pagetic osteoclast formation/activity through suppression of RANK signaling PMID: 18348201
- TRIP6 overexpression in colon tumors suggests its critical role in cancer progression. PMID: 19017743
- IL-12 stimulates the OIP-1 gene expression through STAT-3 activation in CD4+ T cells. PMID: 19259951
- Analysis of the subcellular distribution of ZRP-1 demonstrated that in the absence of endoglin, ZRP-1 mainly localizes to focal adhesion sites, whereas in the presence of endoglin ZRP-1 is found along actin stress fibers. PMID: 15148318
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亞細胞定位：Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus. Cytoplasm.
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蛋白家族：Zyxin/ajuba family
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組織特異性：Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas. Expressed in colonic epithelial cells. Up-regulated in colonic tumors.
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數據庫鏈接：
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