TRIM23 Antibody
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中文名稱：TRIM23兔多克隆抗體
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貨號：CSB-PA024459GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：TRIM23
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別名：ADP ribosylation factor domain protein 1 antibody; ADP-ribosylation factor domain-containing protein 1 antibody; ARF domain protein 1 antibody; ARFD1 antibody; E3 ubiquitin-protein ligase TRIM23 antibody; GTP binding protein ARD 1 antibody; GTP-binding protein ARD-1 antibody; N-acetyltransferase ARD1 human homolog of antibody; N-acetyltransferase homolog of S. cerevisiae ARD1 antibody; RING finger protein 46 antibody; TRI23_HUMAN antibody; TRIM23 antibody; Tripartite motif protein TRIM23 antibody; Tripartite motif-containing protein 23 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Human TRIM23
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes.; (Microbial infection) Mediates TRAF6 auto-ubiquitination in the presence of human cytomegalovirus protein UL144, resulting in the virally controlled activation of NF-kappa-B stimulation at early times of HCMV infection.
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基因功能參考文獻(xiàn)：
- TRIM23 may be associated with progression of gastric cancer PMID: 30477642
- work identifies the TRIM23-TBK1-p62 axis as a key component of selective autophagy and further reveals a role for K27-linked ubiquitination in GTPase-dependent TBK1 activation PMID: 28871090
- Our results indicate that TRIM23 enzymatic activity requires RING dimerization, consistent with the general model of TRIM activation PMID: 28681414
- TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARgamma2. PMID: 25905670
- conclude that TRIM23-mediated ubiquitin conjugation to NEMO is essential for TLR3- and RIG-I/MDA5-mediated antiviral innate and inflammatory responses PMID: 20724660
- Data are consistent with a potential function for ADP-ribosylation factor domain protein 1 as an E3 ubiquitin ligase in cells. PMID: 15684077
- The authors present a novel role for TRIM23 that is specific to UL144-mediated activation of NF-kappaB during the course of virus infection. PMID: 19176615
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亞細(xì)胞定位：Cytoplasm. Endomembrane system. Golgi apparatus membrane. Lysosome membrane. Note=Membrane-associated with the Golgi complex and lysosomal structures.
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蛋白家族：Small GTPase superfamily, Arf family
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數(shù)據(jù)庫鏈接：
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