TRIM11 Antibody

中文名稱：

TRIM11兔多克隆抗體
貨號：

CSB-PA856931LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA856931LA01HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TRIM11 Polyclonal antibody
Uniprot No.：

Q96F44
基因名：

TRIM11
別名：

BIA 1 antibody; BIA1 antibody; E3 ubiquitin protein ligase TRIM11 antibody; E3 ubiquitin-protein ligase TRIM11 antibody; Protein BIA1 antibody; RING finger protein 92 antibody; RING type E3 ubiquitin transferase TRIM11 antibody; RNF 92 antibody; RNF92 antibody; TRI11_HUMAN antibody; Trim 11 antibody; TRIM11 antibody; Tripartite motif containing 11 antibody; tripartite motif protein 11 antibody; Tripartite motif-containing protein 11 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human E3 ubiquitin-protein ligase TRIM11 protein (267-468AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，TRIM11 Antibody (CSB-PA856931LA01HU)，的標記方式是Non-conjugated。對于TRIM11 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA856931LB01HU	TRIM11 Antibody, HRP conjugated	ELISA
FITC	CSB-PA856931LC01HU	TRIM11 Antibody, FITC conjugated
Biotin	CSB-PA856931LD01HU	TRIM11 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.
基因功能參考文獻：
1. findings identify TRIM11 as an important activator of the proteasome, define a pathway that adjusts proteasome activity, and reveal a mechanism by which tumor cells acquire higher degradative power to support oncogenic growth PMID: 29581427
2. Data show that miR-24-3p downregulation contributes to tripartite motif-containing protein 11 (TRIM11) upregulation in cancer (CC). PMID: 27888625
3. TRIM11 promotes the development and progression of HCC through regulating p53 and its downstream signals. PMID: 29190611
4. data showed that tripartite motif-containing protein 11(TRIM11) expression was significantly elevated in hepatocellular carcinoma(HCC) tissues and overexpression of TRIM11 is closely associated with HCC progression and poor survival PMID: 28065743
5. Results show that TRIM11 was highly expressed in lung cancer tissues and cell lines and suggest that it acts as an oncogene in lung cancer through promoting cell growth, migration and invasion. PMID: 27329103
6. TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via p62-dependent selective autophagy. PMID: 27498865
7. TRIM11 to be overexpressed in HCC tissues and cell lines. Downregulation of TRIM11 inhibited HCC cell proliferation and invasion in vitro and in vivo as well as suppressed the epithelial-mesenchymal transition (EMT) process. PMID: 28244856
8. study identified TRIM11 as a new HIV-1 capsid binding protein; data also reveal that TRIM11 restricts HIV-1 reverse transcription by accelerating viral uncoating, and microtubule dynamics is implicated in TRIM11-imposed block to early events of HIV-1 replication PMID: 27737691
9. TRIM11 is a host cellular factor that interferes with the early steps of HIV-1 replication and provides a connection between viral protein and host antiviral factors. PMID: 25105968
10. TRIM11 is overexpressed in high-grade gliomas and promotes proliferation, invasion, migration and glial tumor growth. PMID: 23178488
11. TRIM11 negatively regulates IFN-beta production and antiviral activity by targeting TBK1. PMID: 23675467
12. Study shows that the E3 ubiquitin ligase TRIM11 plays a critical role in the clearance of mutant PHOX2B, which causes congenital central hypoventilation syndrome, through the proteasome. PMID: 22307522
13. PAX6 interacts with HOMER3, DNCL1, and TRIM11. Three C-terminal PAX6 mutations, previously identified in patients with eye malformations, all reduced or abolished the interactions. PMID: 16098226
14. These results suggest that TRIM11, with the ubiquitin-proteasome pathway, regulates ARC105 function in TGFbeta signaling. PMID: 16904669
15. Downregulation of TRIM11 and TRIM15 enhanced virus release suggesting that these proteins contribute to the endogenous restriction of retroviruses in cells. PMID: 18248090
16. This study suggests a potential role for Trim11 in the specification of NA phenotype by interaction with Phox2b. PMID: 18275850
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亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

TRIM/RBCC family
組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 16281

OMIM: 607868

KEGG: hsa:81559

STRING: 9606.ENSP00000284551

UniGene: Hs.13543

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