TRAPPC9 Antibody

說(shuō)明書(shū)

中文名稱：

TRAPPC9兔多克隆抗體
貨號(hào)：

CSB-PA842741LA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA842741LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA842741LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) TRAPPC9 Polyclonal antibody
Uniprot No.：

Q96Q05
基因名：

TRAPPC9
別名：

TRAPPC9 antibody; KIAA1882 antibody; NIBP antibody; T1 antibody; Trafficking protein particle complex subunit 9 antibody; NIK- and IKBKB-binding protein antibody; Tularik gene 1 protein antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Trafficking protein particle complex subunit 9 protein (780-1030AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，TRAPPC9 Antibody (CSB-PA842741LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于TRAPPC9 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA842741LB01HU	TRAPPC9 Antibody, HRP conjugated	ELISA
FITC	CSB-PA842741LC01HU	TRAPPC9 Antibody, FITC conjugated
Biotin	CSB-PA842741LD01HU	TRAPPC9 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi.
基因功能參考文獻(xiàn)：
1. CNVs significantly contribute to the mutational spectrum of TRAPPC9 gene associated with syndromic intellectual disability. PMID: 29187737
2. Data show that NIBP expression level is high in gastric cancer (GC) patients and indicate that the NIBPregulated NFkappaB signaling pathway plays a pivotal role in the chemoresistance of GC cells by promoting EMT. PMID: 29620292
3. Homozygous TRAPPC9 gene nonsense mutation in OXTR gene is associated with intellectual disability, speech disorder, and secondary microcephaly. PMID: 29031008
4. In this study, we report that WES analysis allowed identification of the causal molecular lesion in both patients. In the first family of Egyptian origin, a homozygous nonsense mutation (c.1423C>T; p.Arg377*) in TRAPPC9 was identified PMID: 27108886
5. In conclusion, we demonstrated that NIBP knockdown reduces colorectal cancer metastasis through down-regulation of canonical NF-kappaBeta signaling and suppression of ERK and JNK signaling. PMID: 28125661
6. NIBP impacts on the expression levels of Ecadherin, CD44 and vimentin via the NFkappaB classical and alternative pathways. PMID: 27109343
7. NIBP reflects a higher metastatic potential of CRC tumors, and its mechanism of action may be through regulation of the classical NF-kappaB pathway and increased MMP-2 and MMP-9 expression PMID: 26596835
8. Data identified important roles of NIBP in promoting tumorigenesis via NFkappaBeta signaling. PMID: 25704885
9. Identification and construction of a 3D protein model of trafficking protein particle complex 9 (TRAPPC9), a potetnially interesting molecular target for the development of drug therapy against non syndromic mental retardation PMID: 24040793
10. By detailed phenotypic analysis of our patients, and by critical literature review, we found that homozygous TRAPPC9 loss-of-function mutations cause a distinctive phenotype, characterized by peculiar facial appearance, obesity, hypotonia PMID: 22549410
11. A homozygous splice site mutation in TRAPPC9 causes intellectual disability and microcephaly. PMID: 22989526
12. Data suggest that TRAPPC9 serves to uncouple p150(Glued) from the COPII coat, and to relay the vesicle-dynactin interaction at the target membrane. PMID: 22279557
13. Data show that a disease-causing mutation of TRAPPC2, D47Y, failed to interact with either TRAPPC9 or TRAPPC8, suggesting that aspartate 47 in TRAPPC2 is at or near the site of interaction with TRAPPC9 or TRAPPC8. PMID: 21858081
14. Studies indicate that a truncation of TRAPPC9 leads to mental retardation. PMID: 20966969
15. TRAPPC9 has a role in brain development, possibly through its effect on NF-kappaB activation and protein trafficking in the postmitotic neurons of the cerebral cortex PMID: 20004763
16. TRAPPC9, encodes the NIK- and IKK-beta-binding protein, has a role in nonsyndromic autosomal-recessive mental retardation PMID: 20004765
17. NIBP is a NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation PMID: 15951441
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相關(guān)疾病：

Mental retardation, autosomal recessive 13 (MRT13)
亞細(xì)胞定位：

Golgi apparatus, cis-Golgi network. Endoplasmic reticulum. Cytoplasm.
蛋白家族：

NIBP family
組織特異性：

Expressed at high levels in muscle and kidney and to a lower extent in brain, heart and placenta.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 30832

OMIM: 611966

KEGG: hsa:83696

STRING: 9606.ENSP00000373979

UniGene: Hs.654911

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