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中文名稱：TRAF7兔多克隆抗體
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貨號：CSB-PA780056
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) TRAF7 Polyclonal antibody
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Uniprot No.：
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基因名：TRAF7
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別名：E3 ubiquitin protein ligase TRAF7 antibody; E3 ubiquitin-protein ligase TRAF7 antibody; RFWD1 antibody; Ring finger and WD repeat domain 1 antibody; RING finger and WD repeat-containing protein 1 antibody; RING finger protein 119 antibody; RNF119 antibody; TNF receptor associated factor 7 antibody; TNF receptor-associated factor 7 antibody; TRAF7 antibody; TRAF7_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human, Mouse
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免疫原：Synthesized peptide derived from part region of human protein
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：ELISA, WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
引用文獻
- Programmable RNA 5-methylcytosine (m5C) modification of cellular RNAs by dCasRx conjugated methyltransferase and demethylase KO Chu,Nucleic acids research,2024
產品評價
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靶點詳情
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功能：E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MAP3K3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed. Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3.
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基因功能參考文獻：
- TRAF7 mutations icause intraneural perineuriomas. PMID: 28019650
- TRAF7 is a direct target of miR-126 in human umbilical cord vascular endothelial cells. PMID: 25318608
- Downregulation of ubiquitin E3 ligase TNF receptor-associated factor 7 leads to stabilization of p53 in breast cancer. PMID: 23128672
- The findings of this study suggested an essential contribution of combined KLF4 K409Q and TRAF7 mutations in the genesis of secretory meningioma and demonstrate a role for TRAF7 alterations in other non-NF2 meningiomas. PMID: 23404370
- Nearly one-fourth of all meningiomas have mutations in TRAF7. PMID: 23348505
- TRAF7 is involved in signal transduction pathways that lead either to activation or repression of NF-kappaB transcription factor. PMID: 22105767
- an important role for TRAF7 in the activation of JNK following TNFalpha stimulation and involvement of this protein in regulating the turnover of c-FLIP PMID: 22219201
- this study identifies TRAF7 as a NEMO- and p65-interacting molecule and brings important information on the ubiquitination events that control NF-kappaB transcriptional activity. PMID: 21518757
- TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis PMID: 15001576
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亞細胞定位：Cytoplasmic vesicle. Note=Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.
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蛋白家族：WD repeat TRAF7 family
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組織特異性：Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta.
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數據庫鏈接：
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