TRAF3IP1 Antibody
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中文名稱：TRAF3IP1兔多克隆抗體
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貨號：CSB-PA984438
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA984438(TRAF3IP1 Antibody) at dilution 1/70, on the right is treated with fusion protein. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA984438(TRAF3IP1 Antibody) at dilution 1/70, on the right is treated with fusion protein. (Original magnification: ×200) -
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human brain malignant glioma tissue, Primary antibody: CSB-PA984438(TRAF3IP1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
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其他：
產品詳情
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Uniprot No.：
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基因名：TRAF3IP1
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別名：Interleukin 13 receptor alpha 1 binding protein 1 antibody; Interleukin-13 receptor alpha 1-binding protein 1 antibody; Microtubule interacting protein that associates with TRAF3 antibody; Microtubule-interacting protein associated with TRAF3 antibody; MIP T3 antibody; MIP-T3 antibody; MIPT3 antibody; MIPT3_HUMAN antibody; TNF receptor associated factor 3 interacting protein 1 antibody; TRAF3-interacting protein 1 antibody; Traf3ip1 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Fusion protein of Human TRAF3IP1
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:10000 WB 1:500-1:2000 IHC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. Involved in ciliogenesis.
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基因功能參考文獻：
- Mutations in TRAF3IP1 are identified in patients with nephronophthisis and retinal degeneration. The identified mutations result in mild ciliary defects in patients and reveal a role of IFT54 as a negative regulator of microtubule stability via MAP4. PMID: 26487268
- MIP-T3 functions as a negative regulator of the innate type I interferon response by preventing TRAF3 from forming protein complexes with critical downstream transducers and effectors of antiviral response. PMID: 22079989
- Data show that MIP-T3 protein level is highly regulated; mainly mediated by the ubiquitin-proteasome system. PMID: 21510943
- The interaction of MIP-T3 with both actin filaments and microtubule suggested that MIP-T3 may play an important role in regulation of cytoskeleton dynamics in cells. PMID: 20391533
- These results suggest that MIP-T3 is a novel inhibitor of IL-13 signaling and may be a useful molecule in ameliorating various conditions in which IL-13 plays a central role. PMID: 12935900
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相關疾?。?/div>Senior-Loken syndrome 9 (SLSN9)亞細胞定位：Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body.蛋白家族：TRAF3IP1 family組織特異性：Ubiquitous.數據庫鏈接：
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