TPTE2 Antibody, FITC conjugated
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中文名稱：TPTE2兔多克隆抗體, FITC偶聯
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貨號：CSB-PA757850LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) TPTE2 Polyclonal antibody
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Uniprot No.：
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基因名：TPTE2
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別名：TPTE2; TPIP; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2; Lipid phosphatase TPIP; TPTE and PTEN homologous inositol lipid phosphatase
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 protein (167-411AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate.; Shows no phosphoinositide phosphatase activity.
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基因功能參考文獻：
- The role of TPTE2 in gallbladder cancer cells PMID: 25676706
- TPTE2 was originally reported to be a phosphoinositide 3'-phosphatase, like the tumor suppressor PTEN. Later on, other homologous phosphatases, such as Ci-VSP and Dr-VSP, have been described. These proteins are 5'-phosphatases. More recently, using a chimeric construct, we have shown that the catalytic domain of TPTE2 behaves as a 5'-phosphatase as well. PMID: 22896666
- findings suggest that C2-domain of TPIP-C2 may act as a dominant negative effector, which may bind to and arrest the cell proliferation signalling complex PMID: 22311048
- the TPIP splice-variant (TPIP-C2) mRNA is expressed in human and mouse tissues and strongly inhibits cell growth in HeLa cells PMID: 22164291
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亞細胞定位：[Isoform 3]: Endoplasmic reticulum membrane; Multi-pass membrane protein.; [Isoform 1]: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.; [Isoform 4]: Cytoplasm.
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組織特異性：Isoform 3 is expressed in testis, brain and stomach while isoform 4 seems to be testis-specific.
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數據庫鏈接：
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