TONSL Antibody

中文名稱：

TONSL兔多克隆抗體
貨號：

CSB-PA836224LA01HU
規格：

￥440
圖片：
Immunofluorescent analysis of MCF-7 cells using CSB-PA836224LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TONSL Polyclonal antibody
Uniprot No.：

Q96HA7
基因名：

TONSL
別名：

I kappa B related protein antibody; I-kappa-B-related protein antibody; IkappaBR antibody; IKBR antibody; Inhibitor of kappa B related protein antibody; Inhibitor of kappa B-related protein antibody; MMS22L-interacting protein antibody; MMS22L-interacting protein, NFBIL2/TONSL antibody; NF kappa B inhibitor like protein 2 antibody; NF-kappa-B inhibitor-like protein 2 antibody; NFBIL2 antibody; NFBIL2/TONSL antibody; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like protein 2 antibody; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2 antibody; Protein IkappaBR antibody; Tonsl antibody; TONSL_HUMAN antibody; Tonsoku-like protein antibody; tonsoku-like, DNA repair protein antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Tonsoku-like protein (668-955AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，TONSL Antibody (CSB-PA836224LA01HU)，的標記方式是Non-conjugated。對于TONSL Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA836224LB01HU	TONSL Antibody, HRP conjugated	ELISA
FITC	CSB-PA836224LC01HU	TONSL Antibody, FITC conjugated
Biotin	CSB-PA836224LD01HU	TONSL Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold.
基因功能參考文獻：
1. By specifically regulating RAD51 activity at uncoupled replication forks, MMS22L-TONSL stabilizes perturbed replication forks by promoting replication fork reversal and stimulating their homologous recombination-mediated restart in vivo. PMID: 27797818
2. new histones incorporated during DNA replication provide a signature of post-replicative chromatin, read by the human TONSL-MMS22L homologous recombination complex PMID: 27338793
3. Common NFKBIL2 polymorphisms are associated with susceptibility to invasive pneumococcal infection. PMID: 21171993
4. Results strongly suggest that the Mms22L-Nfkbil2 complex contributes to genome stability by regulating the chromatin state at stalled replication forks. PMID: 21113133
5. These results indicate that MMS22L and TONSL are genome caretakers that stimulate the recombination-dependent repair of stalled or collapsed replication forks. PMID: 21055983
6. MMS22L and TONSL are required for the maintenance of genome stability. PMID: 21055984
7. This study identifies MMS22L-NFKBIL2 as components of the replication stress control pathway. PMID: 21055985
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亞細胞定位：

Cytoplasm. Nucleus. Note=Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks.
蛋白家族：

Tonsoku family
組織特異性：

Expressed in heart, skeletal muscle and tracheal epithelial cells.
數據庫鏈接：

HGNC: 7801

OMIM: 604546

KEGG: hsa:4796

STRING: 9606.ENSP00000386239

UniGene: Hs.675285

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