TOMM70 Antibody

說明書

中文名稱：

TOMM70兔多克隆抗體
貨號：

CSB-PA024055ESR2HU
規格：

￥440
圖片：
Western blot
All lanes: TOMM70A antibody at 6µg/ml + MCF-7 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 67 kDa
Observed band size: 67 kDa
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TOMM70 Polyclonal antibody
Uniprot No.：

O94826
基因名：

TOMM70
別名：

TOMM70; KIAA0719; TOM70; TOMM70A; Mitochondrial import receptor subunit TOM70; Mitochondrial precursor proteins import receptor; Translocase of outer membrane 70 kDa subunit; Translocase of outer mitochondrial membrane protein 70
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Mitochondrial import receptor subunit TOM70 protein (60-340AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Acts as receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner. Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection. Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis.
基因功能參考文獻：
1. Collectively, this study characterizes a novel protein complex, Tom70/Hsp90/IRF3/Bax, that is important for Sendai virus-induced apoptosis. PMID: 25609812
2. Tom70 acts as a molecular switch that orchestrates hypertrophic stresses and mitochondrial responses to determine pathological cardiac hypertrophy. PMID: 25022898
3. Blockade of mitochondrial protein import triggers the recruitment of PARK2, by PINK1, to the TOMM machinery. PMID: 24149440
4. PINK1 is imported into mitochondria by a unique pathway that is independent of the TOM core complex but crucially depends on the import receptor Tom70 PMID: 23472196
5. The hepatitis C virus NS3/4A protein induced Tom70 expression. PMID: 22032846
6. used biophysical tools to study the interaction between the C-terminal domain of Hsp90 (C-Hsp90), which contains the EEVD motif that binds to TPR domains, and the cytosolic fragment of Tom70 PMID: 21781956
7. This study revealed a novel finding, that is, human TOM70 is linked with the hepatitis C virus NS3 protein and the apoptotic response. PMID: 21412788
8. Tom70 as a critical adaptor linking MAVS to TBK1/IRF3, revealing that mitochondrion is evolutionarily integrated with innate immunity. PMID: 20628368
9. results indicate that the Tom70 monomers are the functional form of the receptor, whereas the homodimers appear to be a minor population, and may represent an inactive state PMID: 20504278
10. TOMM70A is ubiquitously expressed in human tissues, maps on chromosome 3q13.1-q13.2 and consists of 12 coding exons spanning over 37 kb. PMID: 12200962
11. The internal EELD domain facilitates mitochondrial targeting of Mcl-1 via a Tom70-dependent pathway. PMID: 16822835
12. suggests a novel active role for Hsp90 in import steps subsequent to Tom70 targeting. PMID: 16968702
13. S100A2 and S100A6 interact with another TPR protein Tom70 and regulate the Tom70-ligand interaction in vitro PMID: 18669640
14. nuclear respiratory factor-2 binding site methylation suppresses the promoter activity of the human TOMM70 gene PMID: 18852034
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亞細胞定位：

Mitochondrion outer membrane; Single-pass membrane protein.
蛋白家族：

Tom70 family
數據庫鏈接：

HGNC: 11985

OMIM: 606081

KEGG: hsa:9868

STRING: 9606.ENSP00000284320

UniGene: Hs.227253

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