TNS4 Antibody, Biotin conjugated

說明書

中文名稱：

TNS4兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA810319LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TNS4 Polyclonal antibody
Uniprot No.：

Q8IZW8
基因名：

TNS4
別名：

C terminal tensin like antibody; C terminal tensin like protein antibody; C-terminal tensin-like protein antibody; CTEN antibody; FLJ14950 antibody; PP14434 antibody; TENS4_HUMAN antibody; Tensin 4 antibody; Tensin-4 antibody; Tns4 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Tensin-4 protein (20-231AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton. May promote apoptosis, via its cleavage by caspase-3.
基因功能參考文獻：
1. CTEN activated the expression of TGFB1, thereby prompting epithelial-mesenchymal transition in lung adenocarcinoma cancer cells. PMID: 29985912
2. Overexpression of the TNS4 gene is a useful independent predictor of outcomes in patients with stage II/III gastric cancer who undergo surgery and receive adjuvant chemotherapy with S-1. PMID: 29102927
3. Cten-Snail signaling pathway contributes to cell motility in colorectal cancer (CRC), mediated by the stabilization of Snail protein. PMID: 28691764
4. Conclude that in colorectal cancer, Cten is upregulated by EGFR and Kras but downregulated by STAT3. PMID: 26852686
5. Tensin4 is up-regulated by EGF-induced ERK1/2 activity and promotes cell proliferation and migration in hepatocellular carcinoma PMID: 26035355
6. Cten expression mediates invasion of human lung cancer cells and is upregulated by epidermal growth factor via STAT3. PMID: 25439778
7. Findings indicate that induction of Cten protein expression is a relatively early event in melanoma progression, and that Cten has the potential to serve as a prognostic marker for primary melanoma patients. PMID: 24244691
8. Up-regulated cten modulates cell migration induced by FGF2. PMID: 23625726
9. Significant correlation between MET and TNS4 expression in human colon carcinoma and ovarian carcinoma suggests TNS4 plays a critical role in MET stability in cancer. PMID: 24814316
10. CTEN regulates EGFR protein levels through a posttranslational mechanism. PMID: 23774213
11. Phylogenetic analysis, expression patterns, and transcriptional regulation of human CTEN gene. PMID: 23500447
12. Show an oncogenic role for CTEN in pancreatic cancer through promotion of colony formation and cell motility. PMID: 22750970
13. conclude that, in the colon and pancreas, Cten is a downstream target of Kras and may be a mechanism through which Kras regulates of cell motility PMID: 21698197
14. Cten expression is of prognostic significance in colorectal carcinoma, and delineate a Cten-ILK pathway controlling cell motility and possibly promoting metastasis. PMID: 21339732
15. CTEN (C-terminal tensin-like), a novel oncogene overexpressed in invasive breast carcinoma. PMID: 20390342
16. Increased cten mRNA expression was correlated with tumor progression in lung cancers PMID: 12711115
17. Cten/GAPDH mRNA expression was correlated with evidence of tumor progression in thymoma. PMID: 15001839
18. These results provide a novel mechanism whereby the SH2 domain of cten-mediated focal adhesion localization of DLC-1 plays an essential role in its tumor suppression activity. PMID: 17190795
19. Expression of CTEN correlates with high tumor grade and metastasis to lymph nodes, suggesting that CTEN may contribute to tumor invasiveness. PMID: 17765673
20. TNS4 mRNA expression was significantly higher in gastric cancer. PMID: 18612693
21. Cten is a novel nuclear partner of beta-catenin, and has an oncogenic activity in colon cancers. PMID: 19487278
22. CTEN plays an important role in paclitaxel sensitivity, and CTEN expression level may be a prognostic predictive factor for prostate cancer patients. PMID: 19725034
顯示更多

收起更多
亞細胞定位：

Cell junction, focal adhesion. Cytoplasm, cytoskeleton.
組織特異性：

Prostate and placenta. Down regulated in prostate cancer.
數據庫鏈接：

HGNC: 24352

OMIM: 608385

KEGG: hsa:84951

STRING: 9606.ENSP00000254051

UniGene: Hs.438292

Most popular with customers

YWHAB Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF, FC

Species Reactivity: Human, Mouse, Rat
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
XRCC5 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF

Species Reactivity: Human
WT1 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WFDC2 Recombinant Monoclonal Antibody

Applications: ELISA, WB, FC

Species Reactivity: Human
WDR5 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
VIM Recombinant Monoclonal Antibody

Applications: ELISA, IHC, IF

Species Reactivity: Human
VDR Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human