TNNT1 Antibody

說明書

中文名稱：

TNNT1兔多克隆抗體
貨號：

CSB-PA024015GA01HU
規(guī)格：

￥3,900
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

P13805
基因名：

TNNT1
別名：

ANM antibody; MGC104241 antibody; NEM5 antibody; Skeletal antibody; Slow antibody; slow skeletal muscle antibody; Slow skeletal muscle troponin T antibody; sTnT antibody; Tnnt1 antibody; TNNT1_HUMAN antibody; TNT antibody; TnTs antibody; Troponin T antibody; Troponin T slow skeletal muscle antibody; Troponin T type 1 (skeletal slow) antibody; troponin T1 skeletal slow antibody; Troponin T1, slow skeletal type antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Human TNNT1
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
基因功能參考文獻：
1. High TNNT1 expression is associated with breast cancer. PMID: 30031058
2. This study describes the first TNNT1 mutation that transmits in an autosomal dominant fashion to cause nemaline myopathy. PMID: 29178646
3. investigated the effects of one of these mutations, K247R of TnT, on the picosecond dynamics of the Tn core domain (Tn-CD), consisting of TnC, TnI and TnT2 (183-288 residues of TnT), by carrying out the quasielastic neutron scattering measurements on the reconstituted Tn-CD containing either the wild-type TnT2 (wtTn-CD) or the mutant TnT2 (K247R-Tn-CD) in the absence and presence of Ca(2+) PMID: 28923663
4. Data suggest that mutations in troponin C (TnC, A8V) and troponin T (TnT, delta14-TnT) found in patients with hypertrophic cardiomyopathy together fully stabilize the active M state of regulated actin (the actin-tropomyosin-troponin complex). PMID: 28530094
5. pathogenesis of TNNT1 myopathies PMID: 27429059
6. Copeptin and troponin T measurement could potentially improve the prehospital diagnostic and prognostic classification of patients with a suspected AMI. PMID: 27903076
7. TNNT1 genetic and epigenetic variations are associated with HDL-C levels and coronary artery disease. PMID: 26950807
8. Three homologous genes have evolved in vertebrates to encode three muscle type-specific TnT isoforms: TNNT1 for slow skeletal muscle TnT, TNNT2 for cardiac muscle TnT, and TNNT3 for fast skeletal muscle TnT. PMID: 26774798
9. Nemaline body myopathy Palestinian patients were found to have a novel mutation in troponin T1. PMID: 26296490
10. troponin T and creatinine kinase isoenzyme (CK-MB) have roles in combined renal and myocardial injuries in asphyxiated infants PMID: 24625749
11. Biopsy-proven acute and viral myocarditis is associated with elevated concentrations of hs-TnT. PMID: 24781421
12. Troponin T1 blood levels had a positive association with increased risk for hypertrophic cardiomyopathy. PMID: 24020864
13. TNNT1 DNA methylation levels were positively correlated with mean HDL particle size, HDL-phospholipid, HDL-apolipoprotein AI, HDL-C and TNNT1 expression levels. PMID: 23244308
14. Human slow skeletal troponin T (HSSTnT) isoforms, despite being homologues of cardiac TnT may display distinct functional properties in muscle regulation. PMID: 22977240
15. analysis of parameters of oxygen-dependent metabolism of neutrophils by NBT test and levels of vWF antigen in the serum can be used for predicting the risk of unfavorable outcome in patients with ACS and normal troponin T PMID: 22448368
16. In heart failure patients with normal ejection fraction, highly sensitive troponin T and heart fatty acid binding protein are elevated independent of coronary artery disease. PMID: 21729325
17. baseline cTnT levels are higher in patients with MPI evidence of reversible myocardial ischaemia than those without reversible ischaemia PMID: 22239123
18. carotid-femoral pulse wave and office pulse pressure are associated with minimally elevated hsTnT levels in the elderly PMID: 21784424
19. the hypertrophic phenotype associated with the TnT mutations can be characterized by a significant increase in disorder of rigor cross-bridges. PMID: 21683708
20. Elevated serum troponin T levels are associated with different conditions related to the severity of hypertrophic cardiomyopathy. PMID: 21111984
21. Cardiac troponin T and creatine kinase have roles in infarct size and left ventricular function after acute myocardial infarction PMID: 21448949
22. The occurrence of myocardial infarction is associated with elevated troponin T levels. PMID: 19916752
23. Among athletees, faster runners demonstrate significantly stronger cardoac TnT releases and inflammation signs. PMID: 20380359
24. troponin-T mutations were responsible for 3% of the hypertrophic cardiomyopathy cases in our study population PMID: 20038417
25. Troponin T may have a role in pulmonary embolism progeresion to death PMID: 19541721
26. TNT is a biochemical marker of susceptibility to hypoxia in infants of type 1 diabetic mothers. PMID: 19690080
27. Data suggest that inefficient incorporation into myofilament is responsible for the instability of mutant slow troponin T in Amish nemaline myopathy. PMID: 15665378
28. Report adaptation by alternative RNA splicing of slow troponin T isoforms in type 1 but not type 2 Charcot-Marie-Tooth disease. PMID: 18579801
29. slow TnT was encoded by two different transcripts in significantly different ratios in myotonic dystrophy type 1 and myotonic dystrophy type 2 muscles. PMID: 19326042
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相關(guān)疾病：

Nemaline myopathy 5 (NEM5)
蛋白家族：

Troponin T family
數(shù)據(jù)庫鏈接：

HGNC: 11948

OMIM: 191041

KEGG: hsa:7138

STRING: 9606.ENSP00000467176

UniGene: Hs.631558

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