TNNI2 Antibody

說明書

中文名稱：

TNNI2兔多克隆抗體
貨號：

CSB-PA024012ESR2HU
規格：

￥440
圖片：
Western blot
All lanes: TNNI2 antibody at 3.83μg/ml + Mouse skeletal muscle tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 21 kDa
Observed band size: 21 kDa

Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA024012ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA024012ESR2HU at dilution of 1:100

Immunoprecipitating TNNI2 in Mouse skeletal muscle tissue
Lane 1: Rabbit control IgG instead of CSB-PA024012ESR2HU in Mouse skeletal muscle tissue. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-PA024012ESR2HU (8μg) + Mouse skeletal muscle tissue (500μg)
Lane 3: Mouse skeletal muscle tissue (10μg)
其他：

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產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TNNI2 Polyclonal antibody
Uniprot No.：

P48788
基因名：

TNNI2
別名：

AMCD 2B antibody; AMCD2B antibody; DA 2B antibody; DA2B antibody; fast skeletal muscle antibody; Fast twitch skeletal muscle troponin I antibody; fast-twitch isoform antibody; FSSV antibody; fsTnI antibody; TNNI 2 antibody; Tnni2 antibody; TNNI2_HUMAN antibody; tro antibody; Troponin I antibody; Troponin I fast skeletal muscle antibody; Troponin I fast twitch 2 antibody; Troponin I fast twitch isoform antibody; Troponin I fast twitch skeletal muscle isoform antibody; Troponin I skeletal fast antibody; Troponin I type 2 (skeletal fast) antibody; Troponin I type 2 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Troponin I, fast skeletal muscle protein (1-100AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IP

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200
IP	1:200-1:2000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunoprecipitation (IP) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
基因功能參考文獻：
1. Mutations in genes encoding cardiac troponin I (TNNI3) and cardiac troponin T (TNNT2) caused altered troponin protein stoichiometry in patients with dilated cardiomyopathy. TNNI3p.98trunc resulted in haploinsufficiency, increased Ca(2+) -sensitivity and reduced length-dependent activation. TNNT2p.K217del caused increased passive tension. PMID: 28436080
2. TNNI2 gene missense mutation is associated with distal arthrogryposis type 1. PMID: 26374086
3. report the first TNNI2 mutation in classical FSS and describe an atypical adult FSS case with only facial contractures resulting from somatic mosaicism PMID: 23850728
4. Molecular genetic investigations revealed pathogenic mutations in MYH3, TPM2, and TNNI2 in one sporadic and 19 familial cases of distal arthrogryposis. PMID: 22519952
5. Atrial re-expression of ssTnI during paroxysmal atrial fibrillation in patients does not seem to be part of the process of AF-associated cardiomyocyte dedifferentiation but seems to result from transient cardiomyocyte stress at the onset of AF. PMID: 15289369
6. study found a novel TNNI2 mutation in a Chinese family with distal arthrogryposis type 2B PMID: 16802141
7. Implantation of stable human clone expressing fast-twitch skeletal muscle troponin I in female BALB/c nude mice inhibits primary tumor growth and suggests that grafts are self-inhibitory by halting angiogenesis. PMID: 17393089
8. These findings reveal a new function for TNNI2 as a co-activator of ERRalpha. PMID: 18331830
9. Data found that fTnI normally associated with fast twitch skeletal muscle were present at significant levels in the thoracic aorta, and that fTnI transcripts were expressed in the smooth muscle layer of mouse blood vessels of all sizes. PMID: 18548613
10. Gene expression revealed up-regulation of pro-angiogenic (PGF), anti-apoptotics (BAG-1, BCL-2), heart development (TNNT2, TNNC1) and extracellular matrix remodelling (MMP-2, MMP-7) genes in SM. PMID: 18805052
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相關疾病：

Arthrogryposis, distal, 2B (DA2B)
蛋白家族：

Troponin I family
數據庫鏈接：

HGNC: 11946

OMIM: 191043

KEGG: hsa:7136

STRING: 9606.ENSP00000252898

UniGene: Hs.523403

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