TMPRSS11A Antibody
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中文名稱：TMPRSS11A兔多克隆抗體
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貨號：CSB-PA138752
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA138752(TMPRSS11A Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA138752(TMPRSS11A Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
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其他：
產品詳情
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Uniprot No.：
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基因名：TMPRSS11A
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別名：Airway trypsin-like protease 1 antibody; ECRG1 antibody; epidermal type II transmembrane serine protease antibody; Epidermal type-II transmembrane serine protease antibody; Esophageal cancer-susceptibility gene 1 protein antibody; TM11A_HUMAN antibody; Tmprss11a antibody; TMPRSS11A protein antibody; Transmembrane protease serine 11A antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Fusion protein of Human TMPRSS11A
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 IHC 1:25-1:100 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.
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基因功能參考文獻：
- ECRG1 Arg290Gln polymorphism significantly affects the susceptibility but not the prognosis of esophageal squamous cell carcinoma patients in low-risk north Indian population. PMID: 23869757
- This suggests that substitution of the arginine in the conserved catalytic domain of the ECRG1 protein might reduce its catalytic capacity by impacting its 3-dimensional conformation, thereby causing the genetic susceptibility to ESCC. [review] PMID: 23548972
- Data show that the allele types of ECRG1 were Arg/Arg (54.2%), Arg/Gln (45.8%) and Gln/Gln (0.00%), and the allele types of FGFR4 amino acid 388 were Arg/Arg (8.3%), Arg/Gly (54.2%) and Gly/Gly (37.5%). PMID: 23481570
- A statistically significantly increased risk of ESCC was found to be associated with the ECRG1 Arg/Gln and Gln/Gln genotype. PMID: 21517269
- Data show that ECRG4 interacts directly with ECRG1 to upregulate p21 protein expression, induce cell cycle G1 phase block and inhibit cancer cells proliferation in ESCC. PMID: 21288367
- findings indicate that ECRG1 may be a candidate tumor suppressor gene for esophageal cancer involved in cell-cycle control PMID: 17971341
- DNA polymorphisms in the coding region of ECRG1 are associated with poor outcome after surgical resection in esophageal carcinoma. PMID: 19052822
- no significant association between single nucleotide polymorphisms Arg/Arg, Arg/Gln and Gln/Gln and survival in oral squamous cell carcinoma PMID: 19394797
- Observational study of gene-disease association. (HuGE Navigator) PMID: 19826048
- Observational study of gene-disease association. (HuGE Navigator) PMID: 19394797
- Observational study of gene-disease association. (HuGE Navigator) PMID: 19052822
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亞細胞定位：Membrane; Single-pass type II membrane protein.
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蛋白家族：Peptidase S1 family
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組織特異性：Expressed in esophagus, liver, colon and lung. Down-regulated in esophagus cancers.
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數據庫鏈接：
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