TMEM165 Antibody
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中文名稱：TMEM165兔多克隆抗體
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貨號：CSB-PA023739GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：TMEM165
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別名：TMEM165; TPARL; Transmembrane protein 165; Transmembrane protein PT27; Transmembrane protein TPARL
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human TMEM165
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：May function as a calcium/proton transporter involved in calcium and in lysosomal pH homeostasis. Therefore, it may play an indirect role in protein glycosylation.
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基因功能參考文獻：
- High TMEM165 expression is associated with hepatocellular carcinoma. PMID: 30015898
- The finding of numerous splice variants could lead to a family of TMEM165 isoforms. PMID: 28088503
- Data indicate the Golgi protein transmembrane protein 165 (TMEM165) as a manganese-sensitive protein in mammalian cells. PMID: 28270545
- This manuscript is a review of the current state of knowledge on TMEM165 deficiencies in Congenital Disorders of Glycosylation as well as new data on function of TMEM165 and some speculative models on TMEM165/Golgi functions are discussed. PMID: 27401145
- Study not only provides novel insights into the molecular causes of glycosylation defects observed in TMEM165-deficient cells but also suggests that TMEM165 is a key determinant for the regulation of Golgi Mn(2+) homeostasis. PMID: 27008884
- Antisense oligonucleotide-mediated pseudoexon skipping used in a Golgi-resident protein, a promising treatment option for a specific TMEM165-congenital disorders of glycosylation. PMID: 24720419
- Congenital Disorders of Glycosylation disease-causing mutations of TMEM165 changes subcellular localization of the protein. PMID: 23575229
- Defects in TMEM165 affect both Ca2+ and pH homeostasis. PMID: 23569283
- we identified TMEM165 (also named TPARL) as a gene involved in congenital disorders of glycosylation (CDG). PMID: 22683087
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相關疾病：Congenital disorder of glycosylation 2K (CDG2K)
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亞細胞定位：Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane. Lysosome membrane. Early endosome membrane. Late endosome membrane.
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蛋白家族：GDT1 family
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組織特異性：Ubiquitously expressed.
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數據庫鏈接：
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