TMC8 Antibody
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中文名稱：TMC8兔多克隆抗體
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貨號(hào)：CSB-PA007390
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規(guī)格：￥1090
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圖片：
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Western Blot analysis of HeLa cells using TMC8 Polyclonal Antibody
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：TMC8
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別名：TMC8 antibody; EVER2 antibody; EVIN2 antibody; Transmembrane channel-like protein 8 antibody; Epidermodysplasia verruciformis protein 2 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from the C-terminal region of Human TMC8.
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：WB, IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:5000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Probable ion channel.
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基因功能參考文獻(xiàn)：
- The relatively high proportion of EV patients without mutation in TMC6/8 indicates the existence of EV-causing mutations in additional, presently unknown gene(s). However, a homozygous TMC8 splice site mutation in our patients resulted in aberrant transcripts which cannot retain the healthy phenotype PMID: 28646613
- The present study did not show any significant association of the EVER1/2 polymorphisms (rs2290907and rs16970849) with cervical cancer. PMID: 27899077
- There were no differences in Ever2 SNPs between head and neck squamous cell carcinoma patients with human papilloma virus (HPV)-positive and HPV-negative tumors, and healthy controls. PMID: 27097911
- Findings suggest that SNPs in EVER2 may be involved in the development of premalignant skin lesions that harbour beta-HPV, perhaps giving rise to SCC tumours that have lost beta-HPV gene expression during progression. PMID: 26126409
- TMC6/EVER1 and TMC8/EVER2 are known to be involved in the development of EV. PMID: 26227733
- A common genetic variation in TMC8 is associated with high-risk HPV infection and head and neck squamous cell carcinoma etiology. PMID: 25853559
- We found a possible correlation between the EVER2 TT genotype and the development of AK, suggesting a potential role of this polymorphism in the development of AK. PMID: 25495765
- EV is also a rare autosomal recessive genodermatosis involving susceptibility to human papillomavirus (HPV) infections and squamous cell carcinoma, caused in most cases by homozygous mutations in EVER1 or EVER2. PMID: 23534907
- TMC8 was found to be localized in the endoplasmic reticulum (ER), where it inhibited receptor mediated Ca(2+) release, activation of Ano1 and volume regulated LRRC8-related Cl(-) currents. PMID: 25220380
- Expression of both EVER1 and EVER2 in B cells is activated immediately after Epstein-Barr virus (EBV) infection, whereas at later stages, it is strongly repressed by latent membrane protein 1-activated NF-kappaB signaling. PMID: 25378492
- Loss of the HPV-infection resistance EVER2 protein impairs NF-kappaB signaling pathways in keratinocytes. PMID: 24586810
- We report a case of Merkel cell polyomavirus detection in the skin of a patient with epidermodysplasia verruciformis (EDV) and a family history remarkable for an unusual inheritance pattern for EDV. PMID: 23535066
- Ever2 interacts with the N-terminal domain of TRADD, impairs the recruitment of TRAF2 and RIPK1 and promotes apoptosis. PMID: 23429285
- EVER2-deficient patients display mild T-cell abnormalities: a significant increase of memory CD4+ and effector memory CD8+ T cells, a bias of the T cell receptor Valphabeta and Vgammadelta repertoires and an increase of skin-homing CD4+ T-cell subsets. PMID: 22903682
- EVER proteins appear as key components of the activation-dependent regulation of Zn(2+) concentration in T cells. However, the impact of EVER-deficiency in T cells on EV pathogenesis remains to be elucidated PMID: 22761942
- study describes the presence of two previously unreported homozygous mutations in the EVER2 gene in two Italian epidermodysplasia verruciformis patients, each of whom have already developed more than 10 non-melanoma skin cancers PMID: 22158547
- Data support the involvement of the TMC6/8 region in cervix cancer susceptibility. PMID: 21387292
- Results underline the possible relevance of the EVER2/TMC8 single nucleotide polymorphism rs7208422 in influencing susceptibility to beta-papillomaviruses and their oncogenic potential. PMID: 21196704
- Mutations in EVER2 are associated with epidermodysplasia verruciformis. PMID: 12426567
- study reports a novel nonsense mutation of the TMC8 gene in Brazilian patients with epidermodysplasia verruciformis PMID: 17711520
- Genetic variation in the EVER2 gene is associated with squamous cell carcinoma of the skin PMID: 18224692
- epidermodysplasia verruciformis in a father and a son with typical histologic and clinical findings that occur in the absence of mutations in EVER1 or EVER2. PMID: 19706093
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相關(guān)疾?。?/div>Epidermodysplasia verruciformis (EV)亞細(xì)胞定位：Endoplasmic reticulum membrane; Multi-pass membrane protein.蛋白家族：TMC family組織特異性：Expressed in placenta, prostate and testis.數(shù)據(jù)庫(kù)鏈接：
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