TLR13 Antibody
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中文名稱：TLR13兔多克隆抗體
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貨號：CSB-PA080183
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規格：￥1090
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圖片：
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Immunohistochemical analysis of paraffin-embedded Mouse Spleen Tissue using TLR13 Polyclonal Antibody.
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其他：
產品詳情
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Uniprot No.：
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基因名：Tlr13
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別名：Tlr13 antibody; Toll-like receptor 13 antibody; EC 3.2.2.6 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Recombinant Protein
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
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產品提供形式：Liquid
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應用范圍：IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution IHC 1:200-500 ELISA 1:10000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Component of innate and adaptive immunity that recognizes and binds 23S rRNA from bacteria. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Specifically binds the 5'-CGGAAAGACC-3' sequence on bacterial 23S rRNA, a sequence also bound by MLS group antibiotics (including erythromycin). May also recognize vesicular stomatitis virus; however, these data require additional evidences.
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基因功能參考文獻：
- Structure of the mouse Toll-like receptor 13 ectodomain in complex with a conserved sequence from bacterial 23S ribosomal RNA has been presented. PMID: 26676765
- S. pyogenes is initially recognized in a phagocytosis-independent manner by TLR2 and subsequently by TLR13 upon internalization. PMID: 25756897
- TLR13 expressed by immune cells detects bacterial RNA with exquisite sequence specificity. PMID: 23110254
- These data lend support to the conclusion that TLR13 participates in group B streptococcus recognition, although blockade of the function of this receptor can be compensated for by other endosomal toll-like receptors. PMID: 25225249
- TLR13 activation contributes to the innate response to Gram-positive bacteria, identifying TLR13 as a receptor for bacterial RNA. PMID: 22896636
- these results show that the orphan receptor TLR13 in mice recognizes a conserved 23S ribosomal RNA (rRNA) sequence that is the binding site of macrolide, lincosamide, and streptogramin group (MLS) antibiotics (including erythromycin) in bacteria. Notably PMID: 22821982
- the potential role of the novel Toll-like receptor tlr13 in the recognition of viral infection. PMID: 21131352
- These findings reveal the mechanism of Tlr13 gene regulation, thereby providing insight into the function of Tlr13 in the immune response to pathogen. PMID: 19487701
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亞細胞定位：Endosome membrane; Single-pass type I membrane protein.
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蛋白家族：Toll-like receptor family
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數據庫鏈接：
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Species Reactivity: Human, Mouse, Rat
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