TLN2 Antibody

中文名稱：

TLN2兔多克隆抗體
貨號：

CSB-PA897282HA01HU
規格：

￥440
圖片：
Western blot
All lanes: TLN2 antibody at 12μg/ml
Lane 1: Hela whole cell lysate
Lane 2: Jurkat whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 272 kDa
Observed band size: 230 kDa

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA897282HA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA897282HA01HU at dilution of 1:100
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TLN2 Polyclonal antibody
Uniprot No.：

Q9Y4G6
基因名：

TLN2
別名：

DKFZp451B1011 antibody; DKFZp686I0976 antibody; DKFZp686K0979 antibody; ILWEQ antibody; KIAA0320 antibody; Talin-2 antibody; talin2 antibody; TLN 2 antibody; TLN2 antibody; TLN2_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Talin-2 protein (88-406AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，TLN2 Antibody (CSB-PA897282HA01HU)，的標記方式是Non-conjugated。對于TLN2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA897282HB01HU	TLN2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA897282HC01HU	TLN2 Antibody, FITC conjugated
Biotin	CSB-PA897282HD01HU	TLN2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity.
基因功能參考文獻：
1. The central role of talin and vinculin in cell adhesions suggests that the disintegration of the tissue in atherosclerosis could be partially driven by downregulation of these genes, leading to loosening of cell-ECM interactions and remodeling of the tissue. PMID: 27816808
2. These results suggest that a strong interaction of talin2 with integrins is required to generate traction, which in turn drives invadopodium-mediated matrix degradation, which is key to cancer cell invasion. PMID: 27694340
3. data suggest a potential molecular link between TLN2 and camptodactyly pathogenesis. PMID: 27223613
4. Both TLN-1 and TLN-2 levels correlate with tumorigenicity in human HCC, indicating that these molecules constitute important molecular targets for the diagnosis and/or treatment of hepatocellular carcinoma . PMID: 26822056
5. Data indicate the role of vinculin in inducing the talin mediated integrin activation. PMID: 24446374
6. Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload. PMID: 23266827
7. Data show that SCGB3A1 was down-regulated in invasive compared with DCIS, whereas talin 2 (TLN2) and PTGS1 were up-regulated in invasive compared with DCIS. PMID: 21812955
8. This review discusses the general function of talin 1 and talin 2, as well as vinculin/metavinulin, with emphasis on what is understood about their role in the cardiac myocyte and in whole heart. PMID: 19952892
9. Structural diversity in integrin/talin interactions. PMID: 21134644
10. the differential concentration of CSF and serum-talin 2 in the drug-refractory postencephalitic epilepsy group is an intractability-related phenomenon that might be involved in the development of RPEE PMID: 20620133
11. we show that the predominant brain splice variant of PtdInsPKI gamma (PtdInsPKI gamma-90) binds, by means of a short carboxy-terminal peptide, to the FERM domain of talin, and is strongly activated by this interaction PMID: 12422219
12. The F-actin binding capacity of Talin 2 is regulated by intrasteric occlusion of primary actin-binding determinants within the talin I/LWEQ module. PMID: 15581353
13. Talin2 may serve as the link between integrins and the sarcomeric cytoskeletonin stable adhesion complexes in mature striated muscle. PMID: 17183545
14. Data show that TLN2n presents only in the CSF of temporal lobe epilepsy patients. PMID: 19109932
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亞細胞定位：

Cytoplasm. Cell junction, focal adhesion. Cell junction, synapse. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
數據庫鏈接：

HGNC: 15447

OMIM: 607349

KEGG: hsa:83660

STRING: 9606.ENSP00000303476

UniGene: Hs.569438

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