TIPRL Antibody, Biotin conjugated
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中文名稱：TIPRL兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA023569LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) TIPRL Polyclonal antibody
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Uniprot No.：
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基因名：TIPRL
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別名：1810011K17Rik antibody; dJ69E11.3 antibody; MGC3794 antibody; Putative MAPK activating protein PM10 antibody; Putative MAPK-activating protein PM10 antibody; RP1-69E11.1 antibody; Tip antibody; TIP41 antibody; TIP41-like protein antibody; tiprl antibody; TIPRL_HUMAN antibody; TOR signaling pathway regulator antibody; TOR Signaling Pathway Regulator like antibody; Type 2A-interacting protein antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human TIP41-like protein (1-178AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.
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基因功能參考文獻：
- overexpression of TIPRL promotes phosphorylation of H2AX, and increases gamma-H2AX positive foci in response to DNA damage, whereas knockdown of TIPRL inhibits gamma-H2AX phosphorylation PMID: 26717153
- Unlike yeast TIP41, TIPRL has a positive effect on mTORC1 signaling through the association with PP2Ac. PMID: 23892082
- Data indicate that PP2A holoenzyme biogenesis and activity are controlled by five PP2A modulators, consisting of alpha4, PTPA, LCMT1, PME-1 and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled. PMID: 22443683
- TIPRL is highly up-regulated in human HCC samples and cell lines, compared with noncancerous liver tissues. PMID: 22841785
- Observational study of gene-disease association. (HuGE Navigator) PMID: 19536175
- Observational study of gene-disease association. (HuGE Navigator) PMID: 19064610
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亞細胞定位：Cytoplasm.
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蛋白家族：TIP41 family
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數據庫鏈接：
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