TGS1 Antibody
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中文名稱：TGS1兔多克隆抗體
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貨號：CSB-PA023469GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：TGS1
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別名：Cap specific guanine N2 methyltransferase antibody; Cap-specific guanine-N2 methyltransferase antibody; CLL associated antigen KW 2 antibody; CLL-associated antigen KW-2 antibody; DKFZp762A163 antibody; FLJ22995 antibody; HCA137 antibody; Hepatocellular carcinoma associated antigen 137 antibody; Hepatocellular carcinoma-associated antigen 137 antibody; NCOA6IP antibody; Nuclear receptor coactivator 6 interacting protein antibody; Nuclear receptor coactivator 6-interacting protein antibody; PIMT antibody; PIPMT antibody; PRIP interacting protein PIPMT antibody; PRIP interacting protein with methyltransferase domain antibody; PRIP interacting protein with methyltransferase motif antibody; PRIP-interacting protein with methyltransferase motif antibody; SEREX defined antibody; TGS 1 antibody; Tgs1 antibody; TGS1_HUMAN antibody; Trimethylguanosine synthase antibody; Trimethylguanosine synthase homolog (S. cerevisiae) antibody; Trimethylguanosine synthase homolog antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human TGS1
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
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基因功能參考文獻：
- Data highlight the importance of the catalytic activity of PIMT to mediate VEGF effects during endothelial cell migration and tube formation in angiogenesis. PMID: 26738492
- Self-association of Tgs1p and its catalytic activity were prerequisite to bypass the requirement for its accessory factor Swm2p for efficient pre-rRNA processing and snRNA trimethylation. PMID: 26074133
- PIMT was identified as a key player responsible for glycated low density lipoproteins induced vascular endothelial cell apoptosis. PMID: 23922881
- isoforms of the PIMT/Tgs1 protein with an RNA methyltransferase domain function both in the nucleus and in the cytoplasm PMID: 12943661
- The protein L-isoaspartyl (D-aspartyl) methyltransferase (PIMT) is an enzyme that recognizes and repairs the abnormal L-isoaspartyl residues in proteins. PMID: 21204776
- The structure-function data highlight a strictly essential pi-cation interaction between Trp766 and the m(7)G base and a network of important enzymic contacts to the cap triphosphate via Lys646, Tyr771, Arg807, and Lys836. PMID: 20360394
- Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation. PMID: 11912212
- proteasome maturation constitutes a mechanism regulating Tgs1 function by generating Tgs1 species with different substrate specificities, subcellular localizations, and functions. PMID: 18039666
- These results highlight that PIMT expression is regulated by ROS and could primarily act as an antioxidant enzyme. PMID: 18407833
- present a biochemical characterization of the human Tgs1 guanine-N2 methyltransferase reaction and identify individual amino acids required for methyltransferase activity in vitro and in vivo PMID: 18775984
- m(7)GpppA binds via its adenosine moiety to the structurally conserved adenosylmethionine-binding pocket. The m(7) guanosine is unbound. The crystallized TGS1 fragment is catalytically inactive, but a fragment that is 17 AAs longer exhibits activity. PMID: 19307714
- The crystal structure of the substrate bound methyltransferase domain as well as mutagenesis studies provide insight into the catalytic mechanism of TGS1. PMID: 19386620
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亞細胞定位：Cytoplasm. Nucleus, Cajal body. Nucleus, nucleolus.
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蛋白家族：Methyltransferase superfamily, Trimethylguanosine synthase family
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組織特異性：Ubiquitously expressed. High expression in heart, skeletal muscle, kidney, liver and placenta.
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數據庫鏈接：
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