TGM4 Antibody

中文名稱：

TGM4兔多克隆抗體
貨號：

CSB-PA023464LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA023464LA01HU diluted at 1:300 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of SH-SY5Y cells with CSB-PA023464LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TGM4 Polyclonal antibody
Uniprot No.：

P49221
基因名：

TGM4
別名：

Dorsal prostate transglutaminase antibody; Dorsal protein 1 antibody; Dp1 antibody; Fibrinoligase antibody; hTGP antibody; Prostate specific transglutaminase antibody; Prostate transglutaminase antibody; Prostate-specific transglutaminase antibody; Protein glutamine gamma glutamyltransferase 4 antibody; Protein-glutamine gamma-glutamyltransferase 4 antibody; TG(P) antibody; TGase P antibody; TGase-4 antibody; TGase4 antibody; Tgm4 antibody; TGM4_HUMAN antibody; TGP antibody; Transglutaminase 4 (prostate) antibody; Transglutaminase 4 antibody; Transglutaminase P antibody; Transglutaminase, prostate antibody; Transglutaminase-4 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Protein-glutamine gamma-glutamyltransferase 4 protein (1-684AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，TGM4 Antibody (CSB-PA023464LA01HU)，的標記方式是Non-conjugated。對于TGM4 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA023464LB01HU	TGM4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA023464LC01HU	TGM4 Antibody, FITC conjugated
Biotin	CSB-PA023464LD01HU	TGM4 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract.
基因功能參考文獻：
1. TGM4 is a prostatic secretory molecule with critical role in male reproduction. PMID: 26084804
2. indicated that transglutaminase 4 may serve as a potential predictor of biochemical recurrence of prostate cancer PMID: 23974364
3. Evidence that the retinoic acid receptor gamma plays a major role in the regulation of the hTGP gene and that presence of the androgen receptor, but not its transcriptional transactivation activity, is critical for hTGP transcription. PMID: 22362749
4. CDKN2A, GATA3, CREBBP, ITGA2, NBL1 and TGM4 were down-regulated in the prostate carcinoma glands compared to the corresponding normal glands PMID: 21743959
5. The presence of TGase-4 has a biological impact on a prostate cancer cell's response to MDA-7. PMID: 21524313
6. TGase-4 expression is intrinsically linked to the activation of RON in prostate cancer cells and that this autoactivation of RON contributes to the increased cell motility in TGase-4 expressing cells. PMID: 20596668
7. The expression status of human transglutaminase 4 in benign prostate hyperplasia (BPH) and prostate cancer was analyzed. PMID: 20177144
8. transglutaminase 4 has a relatively wide profile of expression in human cancer cell lines PMID: 17552366
9. TGase-4 plays a pivotal role in the interaction between endothelial cells and prostate cancer cells, an action which is independent of the ROCK pathway. PMID: 18983858
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蛋白家族：

Transglutaminase superfamily, Transglutaminase family
組織特異性：

Prostate.
數據庫鏈接：

HGNC: 11780

OMIM: 600585

KEGG: hsa:7047

STRING: 9606.ENSP00000296125

UniGene: Hs.438265

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