TGIF2 Antibody, FITC conjugated

說明書

中文名稱：

TGIF2兔多克隆抗體, FITC偶聯
貨號：

CSB-PA884421LC01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TGIF2 Polyclonal antibody
Uniprot No.：

Q9GZN2
基因名：

TGIF2
別名：

5' TG 3' interacting factor 2 antibody; 5''-TG-3''-interacting factor 2 antibody; Homeobox protein TGIF2 antibody; TGF (beta) induced transcription factor 2 antibody; TGF beta induced factor 2 antibody; TGF-beta-induced transcription factor 2 antibody; TGFB induced factor 2 antibody; TGFB-induced factor 2 antibody; Tgif2 antibody; TGIF2_HUMAN antibody; Transforming growth factor beta induced factor 2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Homeobox protein TGIF2 protein (82-222AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.
基因功能參考文獻：
1. Tgifs regulate ciliogenesis and suggests that Evi5l mediates at least part of this effect. PMID: 27956704
2. Authors suggest that miR-148a inhibits OC cell proliferation and invasion partly through inhibition of TGFI2. Therefore, this study highlights the importance of the miR-148a/TGFI2 axis in the malignant progression of OC. PMID: 27712592
3. Data show that TGFB-induced factor 2 protein (TGIF2) is involved in microRNA miR-541-3p-regulated cell proliferation, invasion, migration, as well as cell cycle of non-small lung cancer (NSCLC) cells. PMID: 27448300
4. expression of miR-148a was regulated by DNA methylation and targeted by TGIF2. Its methylation may be a potential prognostic indicator in skin cancer PMID: 26638007
5. miR-34a could inhibit tumor invasion and metastasis in gastric cancer by targeting Tgif2 PMID: 26464633
6. Corneal fibroblasts demonstrate the expression of TGIF1 and TGIF2 transcription factors. These transcriptional repressors are critical, at least partially, in mediating the antifibrotic effect of vorinostat in the cornea. PMID: 26330748
7. Shows that the homologous mouse Tgif2 gene is necessary for gastrulation. PMID: 20040491
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亞細胞定位：

Nucleus. Note=Excluded from nucleoli.
蛋白家族：

TALE/TGIF homeobox family
組織特異性：

Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate.
數據庫鏈接：

HGNC: 15764

OMIM: 607294

KEGG: hsa:60436

STRING: 9606.ENSP00000362979

UniGene: Hs.632264

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