TENM1 Antibody

中文名稱：

TENM1兔多克隆抗體
貨號：

CSB-PA892339LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA892339LA01HU diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TENM1 Polyclonal antibody
Uniprot No.：

Q9UKZ4
基因名：

TENM1
別名：

TENM1 antibody; ODZ1 antibody; TNM1 antibody; Teneurin-1 antibody; Ten-1 antibody; Protein Odd Oz/ten-m homolog 1 antibody; Tenascin-M1 antibody; Ten-m1 antibody; Teneurin transmembrane protein 1) [Cleaved into: Ten-1 intracellular domain antibody; IDten-1 antibody; Ten-1 ICD); Teneurin C-terminal-associated peptide antibody; TCPA-1 antibody; Ten-1 extracellular domain antibody; Ten-1 ECD)] antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Teneurin-1 protein (1-241AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，TENM1 Antibody (CSB-PA892339LA01HU)，的標記方式是Non-conjugated。對于TENM1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA892339LB01HU	TENM1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA892339LC01HU	TENM1 Antibody, FITC conjugated
Biotin	CSB-PA892339LD01HU	TENM1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer.; Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Acts also as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking.; Induces gene transcription activation.
基因功能參考文獻：
1. Taken together, the results indicate that distinct pathways are involved in papillary thyroid cancer progression, and TENM1 is a potential marker of cancer progression. PMID: 28004221
2. ODZ1, a protein that participates in the embryonic development of the brain, is also involved in cancer progression by promoting the growth and invasion capabilities of GSCs via a transcriptional pathway that induces the expression of RhoA and activation of downstream ROCK. PMID: 27641332
3. Results of our study, that describes a new Tenm1 mouse, agree with the hypothesis that TENM1 has a role in olfaction. However, additional studies should be done in larger Congenital general anosmia (CGA) cohorts, to provide statistical evidence that loss-of-function mutations in TENM1 can solely cause the disease in our and other CGA cases PMID: 27040985
4. Data suggest teneurin-1/TENM1 (and possibly TENM3) undergoes proteolysis to TCAPs (teneurin C-terminal associated peptides) that form intercellular adhesive units with latrophilin; signaling via TENM1 TCAPs appears to regulate reproduction. [REVIEW] PMID: 26485751
5. This study identified predicted pathogenic, hemizygous variants on chromosome X in disease genes TENM1. PMID: 25666757
6. Studies indicate that teneurin-1 has been suggested as a candidate target gene for X-lined mental retardation. PMID: 25152333
7. The teneurin-1 intracellular domain binds HINT1, thus switching on MITF-dependent transcription of GPNMB. PMID: 25648896
8. Subsequent analysis showed that the deletion in both cousins was identical and involved the whole SH2D1A gene and a part of the adjacent ODZ1 gene. PMID: 22271700
9. Data show that human teneurin-1 is directly regulated by EMX2 at a conserved promoter region upstream of the transcription start site, and identify and characterize the EMX2 dependent promoter element of human teneurin-1. PMID: 21651764
10. teneurin-1 plays a role in intracellular signaling PMID: 15777793
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亞細胞定位：

Cell membrane; Single-pass membrane protein.; [Ten-1 intracellular domain]: Nucleus. Nucleus speckle. Nucleus matrix. Cytoplasm, cytoskeleton.; [Teneurin C-terminal-associated peptide]: Nucleus. Cytoplasm. Cell membrane.
蛋白家族：

Tenascin family, Teneurin subfamily
組織特異性：

Expressed in fetal brain.
數據庫鏈接：

HGNC: 8117

OMIM: 300588

KEGG: hsa:10178

STRING: 9606.ENSP00000403954

UniGene: Hs.23796

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