TECPR2 Antibody, HRP conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TECPR2 Polyclonal antibody
Uniprot No.：

O15040
基因名：

TECPR2
別名：

TECPR2 antibody; KIAA0297 antibody; KIAA0329 antibody; Tectonin beta-propeller repeat-containing protein 2 antibody; WD repeat-containing protein KIAA0329/KIAA0297 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Tectonin beta-propeller repeat-containing protein 2 protein (516-783AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Probably plays a role as positive regulator of autophagy.
基因功能參考文獻：
1. Whole exome sequencing in an Italian pedigree suggests involvement of TECPR2 in a complex form of progressive motor neuron disease. PMID: 27406698
2. The discovery of additional TECPR2 utations in non-Bukharian patients implies that this disease might be more common than previously appreciated PMID: 26542466
3. Results show that TECPR2 associates with several trafficking components as SEC24D and cooperates with LC3C to regulate ER exit sites and ER export suggesting that TECPR2 functions as molecular scaffold linking early secretion pathway and autophagy. PMID: 26431026
4. The discovered TECPR2 mutation implicates autophagy, a central intracellular mechanism, in spastic paraparesis. PMID: 23176824
相關疾病：

Spastic paraplegia 49, autosomal recessive (SPG49)
蛋白家族：

WD repeat KIAA0329 family
組織特異性：

Detected in skin fibroblast (at protein level).
數據庫鏈接：

HGNC: 19957

OMIM: 615000

KEGG: hsa:9895

STRING: 9606.ENSP00000352510

UniGene: Hs.195667

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