TEAD4 Antibody, FITC conjugated

說明書

中文名稱：

TEAD4兔多克隆抗體, FITC偶聯
貨號：

CSB-PA618010LC01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TEAD4 Polyclonal antibody
Uniprot No.：

Q15561
基因名：

TEAD4
別名：

EFTR 2 antibody; EFTR2 antibody; hRTEF 1B antibody; hRTEF1B antibody; MGC9014 antibody; OTTHUMP00000238119 antibody; OTTHUMP00000238122 antibody; OTTHUMP00000238124 antibody; Related to TEF 1 antibody; Related to TEF1 antibody; Related transcription enhancer factor 1B antibody; RTEF1 antibody; TCF13L1 antibody; TEA domain family member 4 antibody; TEAD 4 antibody; TEAD-4 antibody; TEAD4 antibody; TEAD4_HUMAN antibody; TEF 3 antibody; TEF3 antibody; TEFR 1 antibody; TEFR1 antibody; Transcription factor 13 (SV40 transcriptional enhancer factor) like 1 antibody; Transcription factor 13 like 1 antibody; Transcription factor 13-like 1 antibody; Transcription factor RTEF 1 antibody; Transcription factor RTEF-1 antibody; Transcription factor RTEF1 antibody; Transcriptional enhancer factor 1 related antibody; Transcriptional enhancer factor 3 antibody; Transcriptional enhancer factor TEF 3 antibody; Transcriptional enhancer factor TEF-3 antibody; Transcriptional enhancer factor TEF3 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Transcriptional enhancer factor TEF-3 protein (74-434AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.
基因功能參考文獻：
1. TEAD4, the transcription factor that mediates Hippo-YAP signalling, undergoes alternative splicing facilitated by the tumour suppressor RBM4. PMID: 27291620
2. Combining single site-directed mutagenesis and double mutant analyses, the authors conduct a detailed analysis on the role of several residues located at the YAP:TEAD interface. The results provide quantitative understanding of the interactions taking place at the YAP:TEAD interface and give insights into the formation of the YAP:TEAD complex and more particularly on the interaction between TEAD and the ohm-loop found ... PMID: 28430104
3. Studied the effect of TEAD4 acylation on its interaction with YAP and TAZ; found YAP and TAZ bind in a similar manner to both acylated and non-acylated TEAD4. Also found TEAD4 acylation significantly enhances its stability. PMID: 28960584
4. High TEF3 expression is associated with cell cycle progression and angiogenesis in colon cancer. PMID: 26885617
5. Osmotic stress promotes TEAD4 cytoplasmic translocation via p38 MAPK in a Hippo-independent manner. Stress-induced TEAD inhibition predominates YAP-activating signals and selectively suppresses YAP-driven cancer cell growth. PMID: 28752853
6. The transcription factor TEAD4 regulates a pro-metastasis transcription program in a YAP-independent manner in CRC, thus providing a novel mechanism of TEAD4 transcriptional regulation and its oncogenic role in CRC, independently of the Hippo pathway. PMID: 26387538
7. our work provides a structural basis for understanding the regulatory mechanism of TEAD4-mediated gene transcription PMID: 28368398
8. Our results suggest that TEAD4 plays a role in the pathophysiology of atypical teratoid/rhabdoid tumor, which represents a new insight into the biology of this aggressive tumor PMID: 27966820
9. It was found that the TEAD4-YAP complex in the nuclei may be related closely to transcriptions of G1 arrest-related genes. PMID: 28315328
10. Tead4 cooperates with AP1 transcription factors to coordinate target gene transcription. PMID: 26832411
11. TEAD4 and KLF5, in collaboration, promoted triple negative breast cancer cell proliferation and tumor growth in part by inhibiting p27 gene transcription PMID: 25970772
12. potential anti-oxidation gene and can prevent H2O2-induced endothelial cell oxidative damage by activating Klotho PMID: 26041389
13. TEAD4 overexpression induced p16 in HAoSMCs homozygous for the nonrisk coronary disease allele, but not for the risk allele. PMID: 26487755
14. the peptides TEF3-11-66 and TEF3-1197-434 functioned as two independent activation domains, suggesting that N-terminal domain of TEF3-1 also has transcriptional activation capacity PMID: 25687649
15. Edg-1 is a potential target gene of RTEF-1 and is involved in RTEF-1-induced angiogenesis in endothelial cells. PMID: 24520353
16. the multilevel perturbations of TEAD4 at epigenetic, transcriptional and posttranslational levels may contribute to GC development. PMID: 24325916
17. These data suggest that TFF3 and survivin expressions play a vital role in gastric cancer development, and these two proteins are important markers for prognosis in gastric cancer. PMID: 22996285
18. convergent optimization of the YAP/TAZ TEAD binding site suggests that the similarity in the affinities of binding of YAP to TEAD and of TAZ to TEAD is important for Hippo pathway functionality. PMID: 23780915
19. High TEAD4 expression is associated with Age-Related Macular Degeneration. PMID: 22761647
20. These results show that RTEF-1-stimulated IGFBP-1 expression may be central to the mechanism by which RTEF-1 attenuates blood glucose levels. PMID: 22843786
21. Blocking connexin 43 function inhibited RTEF-1-induced endothelial cell connections and aggregation PMID: 22652601
22. RTEF-1 plays an important role in FGFR1- stimulated vasodilatation. PMID: 22433836
23. RTEF-1 as a regulator of HIF-1alpha transcription PMID: 21540178
24. the RTEF-1-driven increase of VEGF-B plays an important role in communication between the endothelium and myocardium PMID: 21169295
25. TEF3, mainly its nuclear localization, is required for VEGF-A(165)-induced endothelial proliferation, migration, tube formation, and in vivo Matrigel angiogenesis. PMID: 21169383
26. Constitutive activation of alpha1-adrenergic signaling through the RTEF-1 transcription factor results in chronic elevation of PP1beta expression and connexin dephosphorylation. This mechanism may underlie some defects in cardiac conduction. PMID: 15520314
27. Novel RTEF-1 transcripts are present within human ocular vascular endothelial cells and mouse neural retina during normal and retinopathy of prematurity development, and alternatively spliced products are produced under hyperoxic and hypoxic conditions PMID: 17652751
28. The gain of function studies indicated that TEA domain family member 4 activate NR5A1 gene expression. PMID: 18579725
29. TEF3 mediates the expression of Down syndrome candidate region 1 isoform 1 (DSCR1-1L) in endothelial cells PMID: 18840614
30. The paper described several reasons to designate the putative translation initiation codon as the leucine (TTG) codon, which is 7 codons upstream from the isoleucine (ATT) codon. PMID: 8921372
31. The paper described that the ORF of TEF-3 initiates with an ATT codon encoding isoleucine. PMID: 8702974
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亞細胞定位：

Nucleus.
組織特異性：

Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.
數據庫鏈接：

HGNC: 11717

OMIM: 601714

KEGG: hsa:7004

STRING: 9606.ENSP00000352926

UniGene: Hs.94865

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