TCP10L Antibody

說明書

產品詳情

Uniprot No.：

Q8TDR4
基因名：

TCP10L
別名：

TCP10L antibody; PRED77 antibody; T-complex protein 10A homolog 1 antibody; T-complex protein 10A-1 antibody; TCP10A-1 antibody; TCP10-like antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Human TCP10L
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

May be involved in transcriptional regulation. Has in vitro transcription inhibition activity. Acts as a tumor suppressor in hepatocellular carcinoma (HCC) cells.
基因功能參考文獻：
1. TCP10L stabilizes MAD1 protein level through direct interaction, and they cooperatively regulate cell cycle progression. PMID: 26698869
2. Overexpression of TCP10L in hepatocellular carcinoma cells suppressed colony formation, inhibited cell cycle progression through G0/G1 phase, and attenuated cell growth in vivo. PMID: 24565846
3. The result revealed that TCP10L expressed specifically in the human liver and testis PMID: 14586771
4. Data suggest that the biological function of the interaction between T-complex protein 10-like and MAD4 may be to maintain the differentiation state in liver cells. PMID: 15469726
5. The specific expression pattern of TCP10L and interaction with DAPK-3 implies that TCP10L might play crucially important roles in spermatogenesis through its interaction with DAPK-3. PMID: 15910542
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亞細胞定位：

Nucleus.
蛋白家族：

TCP10 family
組織特異性：

Expressed in liver and testis. Expressed in the seminiferous tubules (at protein level).
數據庫鏈接：

HGNC: 11657

OMIM: 608365

KEGG: hsa:140290

STRING: 9606.ENSP00000300258

UniGene: Hs.728804

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