TBC1D1 Antibody

說明書

中文名稱：

TBC1D1兔多克隆抗體
貨號：

CSB-PA082079
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA082079(TBC1D1 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA082079(TBC1D1 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: ×200)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q86TI0
基因名：

TBC1D1
別名：

KIAA1108 antibody; TBC 1 antibody; TBC antibody; TBC1 (tre 2/USP6; BUB2; cdc16) domain family; member 1 antibody; TBC1 antibody; TBC1 domain family member 1 antibody; Tbc1d1 antibody; TBCD1_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthetic peptide of Human TBC1D1
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:40-1:150

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells.
基因功能參考文獻：
1. TBC1D1-Ser(231) phosphorylation and/or 14-3-3 binding partially mediates AMPK-governed glucose homeostasis and muscle glucose uptake in a context-dependent manner. PMID: 27826658
2. data demonstrate heterozygous deactivating TBC1D1 mutations in CAKUT patients with a similar renal and ureteral phenotype, and provide evidence that TBC1D1 mutations may contribute to CAKUT PMID: 26572137
3. AS160 and TBC1D1 phosphorylations were evident 30 min after exercise. PMID: 24876356
4. Data show that TBC1D1 is expressed and phosphorylated in response to glucose in these cells. PMID: 24239544
5. Moderate association of rs9852 indicates an influence of TBC1D1 for antipsychotic-induced weight gain. PMID: 23364847
6. R125W mutation occurs in a location of the TBC1D1 PTB domain that is predicted to have a function in a putative protein:protein interaction. PMID: 23667688
7. Data suggest that insulin increases phosphorylation of signaling nexus TBC1D1 independent of prior exercise or lipid/Intralipid administration. PMID: 22851577
8. TBC1D1 is Ser237 phosphorylated and binding capacity to 14-3-3 protein is increased in skeletal muscle following exercise. PMID: 20837646
9. [review] The question of a mechanism for increased phosphorylation of Ser237-TBC1D1 after exercise has, so far, not had a straightforward experimental approach for a direct answer in humans undergoing in vivo exercise. PMID: 21078596
10. A single bout of exercise regulates TBC1D1 and AS160 phosphorylation on multiple sites in human skeletal muscle. PMID: 21505148
11. Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation. PMID: 21454505
12. coding variant R125W affects obesity susceptibility, delimits the location of an obesity gene at 4q34-35 and identifies a gene/gene interaction that influences the risk for obesity predisposition PMID: 16893906
13. form of Tbc1d1 also inhibited GLUT4 translocation and that this effect also required a functional GAP domain PMID: 17274760
14. These results confirm a putative role of TBC1D1 R125W variant in familial obesity predisposition. PMID: 18325908
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亞細胞定位：

Nucleus.
數據庫鏈接：

HGNC: 11578

OMIM: 609850

KEGG: hsa:23216

STRING: 9606.ENSP00000261439

UniGene: Hs.176503

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