TAPBPL Antibody, HRP conjugated
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中文名稱：TAPBPL兔多克隆抗體, HRP偶聯(lián)
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貨號：CSB-PA887144LB01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) TAPBPL Polyclonal antibody
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Uniprot No.：
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基因名：TAPBPL
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別名：FLJ10143 antibody; TAP binding protein like antibody; TAP binding protein related antibody; TAP binding protein related protein antibody; TAP-binding protein-like antibody; TAP-binding protein-related protein antibody; Tapasin like antibody; Tapasin R antibody; Tapasin Related Protein antibody; Tapasin-like antibody; TAPASIN-R antibody; Tapasin-related protein antibody; TAPBP L antibody; TAPBP R antibody; TAPBP-R antibody; Tapbpl antibody; TAPBPR antibody; TPSNR_HUMAN antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Tapasin-related protein (201-468AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
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靶點詳情
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功能：Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC).
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基因功能參考文獻(xiàn)：
- soluble TAPBPR, consisting of the luminal domain alone, added to intact cells, also functions as an effective peptide editor on surface MHC I molecules. PMID: 30213851
- this study reports the crystal structure of MHC I in complex with the peptide editor TAPBPR (TAP-binding protein-related), a tapasin homolog. PMID: 29025991
- this study presents the x-ray structure of the TAPBPR-MHC I complex, which delineates the central step of catalysis. PMID: 29025996
- The authors identify an interaction between TAPBPR and UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1), a folding sensor in the calnexin/calreticulin quality control cycle that is known to regenerate the Glc1Man9GlcNAc2 moiety on glycoproteins. The results suggest the formation of a multimeric complex, dependent on a conserved cysteine at position 94 in TAPBPR, in which TAPBPR promotes the association of UGT1 with p PMID: 28425917
- It is now clear there are two MHC class I specific peptide editors, tapasin and TAPBPR, intimately involved in controlling peptide presentation to the immune system. PMID: 26439010
- These results support a role of TAPBPR in stabilizing peptide-receptive conformation(s) of MHC-I, permitting peptide editing. PMID: 26869717
- TAPBPR is a new player in the MHC class I presentation pathway. (Review) PMID: 25720504
- The longer TAPBPR protein interacted with MHC class I but was attenuated in its ability to down-regulate surface expression of MHC class I. PMID: 24444341
- the data indicate that TAPBPR and tapasin bind in a similar orientation to the same face of MHC class I. PMID: 24163410
- The function of the tapasin-related protein, TAPBPR, was investigated. PMID: 23401559
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亞細(xì)胞定位：Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Microsome membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Mainly found in endoplasmic reticulum but a minority is found on the cell surface (PubMed:11920573).
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