TAF6L Antibody, Biotin conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TAF6L Polyclonal antibody
Uniprot No.：

Q9Y6J9
基因名：

TAF6L
別名：

TAF6L antibody; PAF65A antibody; TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L antibody; TAF6L antibody; PCAF-associated factor 65-alpha antibody; PAF65-alpha antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L protein (345-433AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF5L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state. Functions with MYC to activate target gene expression through RNA polymerase II pause release.
基因功能參考文獻：
1. immunohistochemical studies suggest that CBP, depending on the balance of nuclear proteins, is a component of AIRE nuclear bodies PMID: 15964547
2. protein kinase C betaII augments NF-kappaB-mediated TNF-alpha-induced transcription of the target gene CCL11, promoting p65 association with the CCL11 promoter, in human airway smooth muscle cells by phosphorylating p300/CBP-associated factor PMID: 18714023
亞細胞定位：

Nucleus.
蛋白家族：

TAF6 family
數據庫鏈接：

HGNC: 17305

OMIM: 602946

KEGG: hsa:10629

STRING: 9606.ENSP00000294168

UniGene: Hs.714400

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