TAF6 Antibody, Biotin conjugated
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中文名稱：TAF6兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA023095LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) TAF6 Polyclonal antibody
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Uniprot No.：
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基因名：TAF6
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別名：TAF6 antibody; TAF2E antibody; TAFII70 antibody; Transcription initiation factor TFIID subunit 6 antibody; RNA polymerase II TBP-associated factor subunit E antibody; Transcription initiation factor TFIID 70 kDa subunit antibody; TAF(II)70 antibody; TAFII-70 antibody; TAFII70 antibody; Transcription initiation factor TFIID 80 kDa subunit antibody; TAF(II)80 antibody; TAFII-80 antibody; TAFII80 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Transcription initiation factor TFIID subunit 6 protein (627-677AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.; Transcriptional regulator which acts primarily as a positive regulator of transcription. Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis. Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1. In contrast, down-regulates transcription of MDM2. Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1. Can also activate transcription and apoptosis independently of TP53. Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA.
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基因功能參考文獻：
- data point to several new RNA elements that can modulate TAF6delta and also reveal a role for RNA secondary structure in the selection of TAF6delta PMID: 25025302
- The transcriptome data uncovered novel links between TAF6delta expression and the Notch, oxidative stress response, integrin, p53, p53 feedback loop 2, and angiogenesis pathways. PMID: 20096117
- a novel protein-protein interaction was observed between TAFII70 (not TAFII80) and GADD45a PMID: 15328371
- TAF6delta has a pivotal node in a signaling pathway that controls gene expression programs and apoptosis in the absence of p53 PMID: 18628956
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相關疾病：Alazami-Yuan syndrome (ALYUS)
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亞細胞定位：Nucleus.; [Isoform 4]: Nucleus.
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蛋白家族：TAF6 family
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數據庫鏈接：
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