TAF4 Antibody
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中文名稱：TAF4兔多克隆抗體
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貨號：CSB-PA105074
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規格：￥2024
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圖片：
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Western blot analysis of extracts from NIH-3T3 cells, using TAF4 antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) TAF4 Polyclonal antibody
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Uniprot No.：
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基因名：TAF4
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from internal of Human TAF4.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Part of the TFIID complex, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone.
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基因功能參考文獻：
- Targeted splicing of hTAF4-TAFH coordinates AS of other TFIID subunits, underscoring the role of TAF4 in synchronised changes of Pol II complex composition essential for efficient cellular reprogramming. PMID: 27499390
- Data suggest that many TATA-box-containing promoters contain a TFIIA recognition element (IIARE) that activates transcription by increasing the recruitment of RNA polymerase II, TFIIA (TF2A1/TF2A2 subunits), TAF4, and P300. (TAF4 = TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1; P300 = E1A binding protein p300) PMID: 28539359
- Inactivation of hTAF4-TAFH domain accelerates differentiation of human neural progenitor cells. PMID: 24696168
- TAF4 isoforms generated by the alternative splicing participate in the conversion of the cellular transcriptional programs from the maintenance of stem cell state to differentiation PMID: 24098348
- These interactions are important to the transcriptional activation of these genes by Rta since introducing TAF4 shRNA substantially reduces the ability of Rta to activate these promoters PMID: 23326574
- Data present the crystal structure of a complex formed by the interacting domains from two subunits of the general transcription factor TFIID, the human TATA binding protein-associated factors hTAF4 (hTAF(II)135) and hTAF12 (hTAF(II)20). PMID: 12237304
- trans-activation of promoters by simian virus 40 small t-antigen may depend on a consensus TATA motif and such promoters recruit the general transcription factor hTAF(II)130/135 PMID: 12810884
- TAF4b incorporation into TFIID induces an open conformation at the lobe involved in TFIIA & putative activator interactions, correlating with differential activator-dependent transcription & promoter recognition by 4b/4-IID. PMID: 18206971
- Findings suggest that DNA binding by TAF4/4b-TAF12 facilitates the association of TFIID with the core promoter of a subset of genes. PMID: 19635797
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亞細胞定位：Nucleus.
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蛋白家族：TAF4 family
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數據庫鏈接：
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