TAF1 Antibody

說明書

中文名稱：

TAF1兔多克隆抗體
貨號：

CSB-PA050202
規(guī)格：

￥1090
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

P21675
基因名：

TAF1
別名：

BA2R antibody; CCG1 antibody; CCGS antibody; Cell cycle G1 phase defect antibody; Cell cycle gene 1 protein antibody; Complementation of cell cycle block G1 to S antibody; DYT3 antibody; N TAF1 antibody; NSCL2 antibody; OF antibody; p250 antibody; TAF 1 antibody; TAF(II)250 antibody; TAF1 antibody; TAF1 RNA polymerase II TATA box binding protein (TBP) associated factor 250kDa antibody; TAF1_HUMAN antibody; TAF2A antibody; TAFII-250 antibody; TAFII250 antibody; TATA box binding protein (TBP) associated factor RNA polymerase II A 250kD antibody; TBP associated factor 250 kDa antibody; TBP-associated factor 250 kDa antibody; Transcription factor TFIID p250 polypeptide antibody; Transcription initiation factor TFIID 250 kDa subunit antibody; Transcription initiation factor TFIID subunit 1 antibody; XDP antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from the Internal region of Human TAF II p250.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:10000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4.
基因功能參考文獻：
1. Our findings highlight the regulatory networks among TFs, lncRNAs, miRNAs, and mRNAs in hepatocellular carcinoma (HCC). Several key molecules, such as hsa-miR-195, lncRNA MALAT1 and TFs TAF1 and HNF4alpha, may contribute to the progression of HCC. PMID: 30249878
2. These data directly link sequence variation within the XDP-specific SVA sequence to phenotypic variability in clinical disease manifestation and provide insight into potential mechanisms by which this intronic retroelement may induce transcriptional interference in TAF1 expression. PMID: 29229810
3. present a case study where a combination of experimental techniques and computational simulations was used to comprehensively characterize the binding and structure-affinity relationships for a series of Bromosporine-based bivalent bromodomain ligands with a bivalent protein, Transcription Initiation Factor TFIID subunit 1 (TAF1). PMID: 29558110
4. The results converge on TAF1 dysfunction in peripheral models of X-linked dystonia-parkinsonism, and provide evidence of altered expression of a canonical gene in this disease. Furthermore, this study illustrates a link between the previously described genetic alterations and TAF1 dysfunction at the transcriptome level. PMID: 26879577
5. TAF1 and TAF1L genes harbored not only somatic mutations but also mutational ITH. PMID: 27571988
6. N-TAF1 expression is impaired in X-linked dystonia-parkinsonism. PMID: 26769797
7. The bromodomains of BRD9, CECR2, and the second bromodomain of TAF1 recognize the longer butyryl mark on histones. In addition, the TAF1 second bromodomain is capable of binding crotonyl marks. PMID: 26365797
8. TAF1 variants are associated with dysmorphic features, intellectual disability, and neurological manifestations. PMID: 26637982
9. are necessary and sufficient to overcome the barrier of species specificity for human rDNA transcription in mouse cells PMID: 24928901
10. TAF1 winged helix domain has intrinsic DNA-binding activity, which depends on characteristic residues that are commonly used by winged helix fold proteins for interacting with DNA. PMID: 25412659
11. the surface of the TAF1-TAF7 complex contains two prominent conserved surface pockets, one of which binds selectively to an inhibitory trimethylated histone H3 PMID: 24927529
12. This study demonistrated that frequencies of polymorphic genotype and allele of TAF1 gene were not different in patients than in control group and that they were not significant for cerebral venous thrombosis. PMID: 23264082
13. As cellular ATP levels recover, TAF1 is able to phosphorylate p53 on Thr55, which leads to dissociation of p53 from the p21 promoter. PMID: 24289924
14. Lower efficiency of microRNA synthesis directed by TATA box or NF-kappaappaB is a consequence of frequent transcription initiations that lead to RNA polymerase II crowding at pause sites and premature termination. PMID: 23831825
15. Although d3-d4 also affect genes potentially related to neurodegenerative processes, their physiologic role as splice variants of TAF1 awaits further exploration PMID: 23184149
16. analysis of phosphorylation-dependent regulation of cyclin D1 and cyclin A gene transcription by TFIID subunits TAF1 and TAF7 PMID: 22711989
17. In the Brazilian population, genetic variations in both uPA and TAFI were not relevant to endometriosis and/or infertility. PMID: 21819230
18. TAF7, until now considered only a TFIID component and regulator of TAF1-dependent transcription, also regulates TAF1-independent transcription PMID: 20937824
19. 285 patients with autosomal -dominant ataxia were examined, and abnormal or borderline expansions of CAG/CAA within TBP were found. PMID: 20587494
20. Results indicate that increased TAF1 expression is associated with progression of human prostate cancers to the lethal castration-resistant state. PMID: 20181722
21. polymorphism of TAF1 gene does not influence the risk of myocardial infarction. PMID: 11871391
22. Evidence that TAF-TATA box-binding protein interactions are required for activated transcription in mammalian cells. PMID: 11909971
23. TAF1 may be involved in the coordinate expression of Pol I- and Pol II-transcribed genes required for protein biosynthesis and cell cycle progression. PMID: 12498690
24. TAFI polymorphisms investigated exerted no thrombogenic influence in pediatric oncology patients. PMID: 14719174
25. TAF1 induces G1 progression in a p53-dependent manner. It interacts with and phosphorylates p53 at Thr-55 in vivo. PMID: 15053879
26. hsTAF1 derepression of transcription requires the leucine zipper domain of c-Jun to bind to the N terminus of hsTAF1 PMID: 15087451
27. TAF1-dependent histone acetylation facilitates transcription factor binding to the Sp1 sites, thereby activating cyclin D1 transcription and ultimately G(1)-to-S-phase progression PMID: 15870300
28. DYT3 is the gene responsible for X-linked recessive dystonia-parkinsonism. PMID: 16366515
29. linkage disequilibrium observed in an African population enabled us to identify the 1583T>A SNP located in 3'UTR. PMID: 16705091
30. Downregulates E3 ubiquitin ligase Mdm2 auto-ubiquitylation, leading to Mdm2 stabilization, and promotes p53-Mdm2 association. PMID: 17237821
31. Reduced neuron-specific expression of the TAF1 gene is associated with X-linked dystonia-parkinsonism PMID: 17273961
32. possible sites in hUBF HMG box 5 that may interact with the first bromodomain of TAF1 were proposed PMID: 17505112
33. Thirty-eight exons code for TAF1. Five downstream exons of yet unknown function can either form transcripts with TAF1 exons or be transcribed independently. Splice variants can include d plus at least 12 TAF1 exons. PMID: 17952504
34. CK2 is tightly associated with TAFII250 and is the principal activity responsible for TAFII250-mediated phosphorylation of Mdm2. PMID: 18548200
35. interacts with human papillomavirus 16 E2 protein. PMID: 18580066
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相關(guān)疾病：

Dystonia 3, torsion, X-linked (DYT3); Mental retardation, X-linked, syndromic, 33 (MRXS33)
亞細胞定位：

Nucleus.
蛋白家族：

TAF1 family
數(shù)據(jù)庫鏈接：

HGNC: 11535

OMIM: 300966

KEGG: hsa:6872

STRING: 9606.ENSP00000276072

UniGene: Hs.158560

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