TACR3 Antibody
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中文名稱：TACR3兔多克隆抗體
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貨號：CSB-PA023070ESR2HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA023070ESR2HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA023070ESR2HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) TACR3 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：TACR3; NK3R; TAC3R; Neuromedin-K receptor; NKR; NK-3 receptor; NK-3R; Neurokinin B receptor; Tachykinin receptor 3
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Neuromedin-K receptor protein (356-465AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.
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基因功能參考文獻：
- Three Single-nucleotide polymorphisms (on chromosomes 3 and 11) were associated with vasomotor menopause symptoms in the African American group. However, 14 Single-nucleotide polymorphisms, all located on chromosome 4 in the tachykinin receptor 3 (TACR3) locus, had similar effect sizes across studies/participants' ancestry. Genetic variation in TACR3 may contribute to the risk of vasomotor menopause symptoms. PMID: 28231077
- observations of interspecies variation in the neurokinin 3 receptor brain localization with more extensive distribution in guinea pig than in primate brain; in the human brain, specific binding to the neurokinin 3 receptor was highest in the amygdala and in the hypothalamus and very low in other regions examined PMID: 26993630
- High NK-3R expression is associated with Oral Squamous Cell Carcinoma. PMID: 29061792
- reduced to an almost undetectable level in polycystic ovary syndrome granulosa cells PMID: 27580802
- Neuropeptide derivatives to regulate the reproductive axis: Kisspeptin receptor (KISS1R) ligands and neurokinin-3 receptor (NK3R) ligands. PMID: 27271543
- results suggest that peripheral sensory nerve-derived TAC3 may affect gingival oral squamous cell carcinoma cells through TACR3 in the bone matrix PMID: 27919954
- None of the 4 single polymorphisms studied in TACR3 are linked directly to puberty onset time, but A63P in TAC3 is statistically associated with precocious puberty. PMID: 25153567
- Elevated CRP is likely a pathogenic factor contributing to preeclampsia by binding to phosphocholinated neurokinin B and preferentially activating NK3R. PMID: 25452470
- data indicate that GPR54 and TACR3 gene mutations are not a frequent cause of ICPP. The identified A/G synonymous SNP (dbSNP ID: rs10407968) located in exon 1 of the gene is not likely to have a pathogenic role in exon splicing PMID: 24434351
- Studies indicate the molecular mechanisms by which NK3R mutations cause GnRH deficiency. PMID: 24376026
- Expression of the gene encoding TACR3 is significantly up-regulated in leiomyomas, compared with matched myometrium. PMID: 23656837
- the rs2765 SNP predicted the degree of impairment of learning and memory in 209 elderly patients with cognitive impairments PMID: 23983264
- Data suggest that mutations in TACR3 and GNRHR are the most common causative mutations in normosmic idiopathic hypogonadotropic hypogonadism in families in Turkey. PMID: 22766261
- report of a Japanese female with hypogonadism(IHH) and compound heterozygous TACR3 mutations and her heterozygous parents; results suggest hypothalamic dysfunction as primary cause for IHH in patients with biallelic TACR3 mutations PMID: 20395662
- NK-3R plays a crucial role in hypothalamic gonadotropin releasing hormone release in humans. PMID: 20194706
- Results found no significant difference in the expression of tachykinins receptors between pre-eclamptic placenta and normal controls. PMID: 16709596
- Our results suggest that TACR3 is unlikely to be related to the development of schizophrenia in the Japanese population. PMID: 18287949
- small nucleotide polymorphisms in the 3' region of tachykinin receptor 3 gene (TACR3) provided significant evidence of association with alcohol dependence PMID: 18422838
- TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction. PMID: 19079066
- Homozygosity for the TACR3 His148Leu mutation leads to failure of sexual maturation in humans, whereas signaling by the mutant receptor in vitro in response to either NKB or senktide is severely impaired. PMID: 19755480
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相關疾病：Hypogonadotropic hypogonadism 11 with or without anosmia (HH11)
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亞細胞定位：Cell membrane; Multi-pass membrane protein.
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蛋白家族：G-protein coupled receptor 1 family
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