Serpinh1 Antibody
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中文名稱：Serpinh1兔多克隆抗體
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貨號：CSB-PA021087LA01MO
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規格：￥440
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圖片：
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Western blot
All lanes: Serpinh1 antibody at 6µg/ml + Jurkat whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 47 kDa
Observed band size: 47 kDa
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其他：
產品詳情
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產品名稱：Rabbit anti-Mus musculus (Mouse) Serpinh1 Polyclonal antibody
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Uniprot No.：
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基因名：Serpinh1
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別名：Serpinh1 antibody; Cbp1 antibody; Hsp47 antibody; Serpin H1 antibody; 47 kDa heat shock protein antibody; Collagen-binding protein antibody; Colligin antibody; Serine protease inhibitor J6 antibody
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宿主：Rabbit
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反應種屬：Mouse, Human
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免疫原：Recombinant Mouse Serpin H1 protein (18-417AA)
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免疫原種屬：Mus musculus (Mouse)
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標記方式：Non-conjugated
本頁面中的產品，Serpinh1 Antibody (CSB-PA021087LA01MO)，的標記方式是Non-conjugated。對于Serpinh1 Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.
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基因功能參考文獻：
- The HSP47 might exert influence on liver fibrosis via the regulation ofendothelin receptor A (ETAR) and endothelin receptor B (ETBR). PMID: 28802097
- miR-29b can reduce collagen biosynthesis during skin wound healing likely via post-transcriptional inhibition of HSP47 expression. PMID: 27477081
- HSP47 appears after a period of certain activities to repair damaged collagen fibers, and the activity was returned to a state of equilibrium at day 30 with significantly diminished expression. Thus, the results suggest that HSP47 is actively involved in homeostasis of periodontal tissue subjected to occlusal overload PMID: 27076780
- Intradermal administration of siHSP47-nanoparticles effectively reduced HSP47 protein expression in skin to normal level. PMID: 26196532
- 2014). Data show that the expression of heat shock protein 47 (HSP47) was increased in the scleroderma mouse model. PMID: 26091621
- Deletion of Hsp47 caused activated hepatic stellate cells to undergo ER stress-mediated apoptosis when autophagy was inhibited PMID: 25525267
- Mouse embryonic stem cell migration and differentiation into smooth muscle cells is induced by the over-expression of HSP47. PMID: 24454956
- Authors conclude that heat shock protein 47 plays an essential role in Schistosoma japonicum-induced hepatic fibrosis in mice. PMID: 24295791
- miR-29b down-regulates HSP47 and LOX expression. PMID: 24650661
- expression patterns of HSP70 and HSP47 in tissues following short-pulse laser irradiation PMID: 23587755
- The pH sensitivity of murine heat shock protein 47 (HSP47) binding to collagen is affected by mutations in the breach histidine cluster. PMID: 23212911
- These results demonstrate that Hsp47 is indispensable for well-organized cartilage and normal endochondral bone formation. PMID: 22492985
- overexpression of HSP47 in keloid fibroblast cells could induce excessive collagen accumulation by enhancing collagen synthesis, which not only presents a possible mechanism of keloid formation PMID: 22295344
- alpha-smooth-muscle-actin-positive myofibroblast of bleomycin-induced pulmonary fibrosis cells may synthesize procollagen in the fibrotic process of bleomycin-treated lungs through upregulation of HSP47 mRNA and play an important role in fibrogenesis. PMID: 20094730
- HSP47 localized in alpha-smooth muscle actin-positive myofibroblasts, F4/80 negative, surfactant protein-A-positive type II pneumocytes, and F4/80-positive macrophages. Cells may play role in fibrotic process through upregulation of HSP47. PMID: 12842808
- Results indicate that Hsp47 is required for the molecular maturation of type IV collagen and suggest that misfolded type IV collagen causes abnormal morphology of embryoid bodies. PMID: 15282337
- type IV collagen in dilated endoplasmic reticulum leads to apoptosis in Hsp47-knockout mouse embryos via induction of CHOP PMID: 15522896
- analysis of the client recognition mechanism of HSP47 PMID: 16326708
- analysis of recognition of the collagen triple helix by chaperone HSP47 PMID: 16484215
- Hsp47 is required for correct folding and prevention of aggregation of type I collagen in the ER. PMID: 16525016
- the HSP47-specific siRNA inhibited expression of HSP47 at the level of mRNA and protein, and furthermore, adenovirus-mediated transfer of siRNA against HSP47 inhibited the expression of type I collagen and formation of scar tissue in animal mod PMID: 18093850
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亞細胞定位：Endoplasmic reticulum lumen.
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蛋白家族：Serpin family
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數據庫鏈接：
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