Scgb3a2 Antibody, HRP conjugated

說明書

中文名稱：

Scgb3a2兔多克隆抗體, HRP偶聯
貨號：

CSB-PA846028LB01MO
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Mus musculus (Mouse) Scgb3a2 Polyclonal antibody
Uniprot No.：

Q920H1
基因名：

Scgb3a2
別名：

Scgb3a2 antibody; Pnsp1 antibody; Ugrp1 antibody; Secretoglobin family 3A member 2 antibody; Pneumo secretory protein 1 antibody; PnSP-1 antibody; Uteroglobin-related protein 1 antibody
宿主：

Rabbit
反應種屬：

Mouse
免疫原：

Recombinant Mouse Secretoglobin family 3A member 2 protein (22-139AA)
免疫原種屬：

Mus musculus (Mouse)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Secreted cytokine-like protein. Binds to the scavenger receptor MARCO. Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast. Strongly inhibits phospholipase A2 (PLA2G1B) activity. Seems to have anti-inflammatory effects in respiratory epithelium. Also has anti-fibrotic activity in lung. May play a role in fetal lung development and maturation. Promotes branching morphogenesis during early stages of lung development. In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
基因功能參考文獻：
1. These results demonstrate that SCGB3A2 has an anti-inflammatory activity in the HDM-induced allergic airway inflammation model, in which SCGB3A2 may modulate the CCR4-CCL17 pathway. PMID: 27820933
2. The pulmonary fibrosis in the Scgb3a2-null mice was more severe than the wild-type controls, thus establishing that SCGB3A2 has anti-fibrotic activity in vivo. PMID: 26559674
3. SCGB3A2 is an anti-fibrotic agent, and suggest a possible therapeutic use of recombinant SCGB3A2 in the treatment of pulmonary fibrosis. PMID: 26178733
4. The results indicate that the loss of SCGB3A2 function was influenced by a modifier gene(s) in mixed genetic background and suggest that SCGB3A2 has anti-inflammatory property. PMID: 25242865
5. SCGB3A2 regulates FSH/LH production in the anterior pituitary lobe. PMID: 24514953
6. Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by transforming growth factor beta signaling down-regulation PMID: 21478551
7. Results demonstrate that SCGB3A2 is a useful marker for diagnosis of pulmonary tumors both in mice and humans. PMID: 20466451
8. UGRP1 does not play a major role in the development of bronchial asthma in our Caucasian population. PMID: 12915772
9. results demonstrate that interleukin-10 induces uteroglobin related protein 1(UGRP1) gene expression in lung epithelial cells through transcription factor T/EBP/NKX2.1-dependent pathway PMID: 15485815
10. UGRP1 is downregulated in inflamed airways, such as allergic asthmatics. PMID: 15531759
11. To assess a potential role for SCGB3A2 during early lung development, wild-type and Nkx2-1-null fetal lungs of early developmental stages were subjected to ex vivo organ culture in the presence of SCGB3A2. PMID: 18535256
12. C/EBPalpha and C/EBPdelta have a role in the synergistic interaction with NKX2-1 in mouse Scgb3a2 gene transcription and lung development PMID: 18632661
13. SCGB3A2 gene may contribute to Graves' disease susceptibility. PMID: 19126779
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亞細胞定位：

Secreted.
蛋白家族：

Secretoglobin family, UGRP subfamily
組織特異性：

Highly expressed in lung where it localizes to epithelial cells of the trachea, bronchus and bronchioles (at protein level). Expressed in club/Clara cells of the bronchioles. Also detected in the anterior and posterior lobes of the pituitary gland where i
數據庫鏈接：

KEGG: mmu:117158

STRING: 10090.ENSMUSP00000038872

UniGene: Mm.210437

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