SV2A Antibody, Biotin conjugated

說明書

中文名稱：

SV2A兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA022978LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SV2A Polyclonal antibody
Uniprot No.：

Q7L0J3
基因名：

SV2A
別名：

KIAA0736 antibody; OTTHUMP00000014065 antibody; SV2 antibody; Sv2a antibody; SV2A_HUMAN antibody; Synaptic vesicle glycoprotein 2 antibody; Synaptic vesicle glycoprotein 2A antibody; Synaptic vesicle protein 2a antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Synaptic vesicle glycoprotein 2A protein (36-149AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.; (Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction. Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1.
基因功能參考文獻：
1. Botulinum neurotoxin type A inhibits synaptic vesicle 2 expression in breast cancer cell lines. PMID: 26339411
2. SV2A expression in the bladder urothelium increases after BoNT-A injection. PMID: 26241848
3. the way LEV analogues may interact with SV2A PMID: 25692762
4. agents that act on the conformation of SV2A might hold great potential in the search for new SV2A-based anticonvulsant therapies PMID: 23530581
5. The newly identified galactose transport capability of SV2A may have an important role in regulating/modulating synaptic function. PMID: 25326386
6. The SV2A/FE65 interaction might play a role in synaptic signal transduction. PMID: 24284412
7. In classical mesial temporal sclerosis 1A, the expression of SV2 isoforms is altered with a marked decrease of SV2A paralleling synaptic loss. PMID: 23617838
8. High SV2A expression is associated with breast cancer. PMID: 23244111
9. This study in the German population provides evidence, at a genetic level, for the involvement of the SV2A gene region in schizophrenia. PMID: 23017826
10. Data report a combined modelling and mutagenesis study that successfully identifies another 11 residues in synaptic vesicle protein 2A that appear to be involved in ligand binding. PMID: 21936812
11. expression of SV2A in tumor and peritumoral tissue is correlated to the clinical response to levetiracetam and predicts levetiracetam efficacy PMID: 21795655
12. the role of SV2A in epileptogenesis in patients with glial tumors is questionable PMID: 20167814
13. We found no association between genetic variation in SV2A and response to levetiracetam or epilepsy predisposition PMID: 18977120
14. The pattern of SV2A immunoreactivity with reduced neuropil expression and altered cellular and subcellular distribution suggests a possible contribution of SV2A to the epileptogenicity of these malformations of cortical development. PMID: 19220410
15. Botulinum toxin type A (BTA) inhibits the growth of LNCaP human PCa cells in vitro and in vivo. BTA acts on the cells by virtue of the BTA receptor, the SV2 protein. PMID: 19399787
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亞細胞定位：

Cell junction, synapse, presynapse. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein.
蛋白家族：

Major facilitator superfamily
數據庫鏈接：

HGNC: 20566

OMIM: 185860

KEGG: hsa:9900

STRING: 9606.ENSP00000358142

UniGene: Hs.516153

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