SUOX Antibody

中文名稱：

SUOX兔多克隆抗體
貨號(hào)：

CSB-PA022954HA01HU
規(guī)格：

￥440
圖片：
Western blot
All lanes: SUOX antibody at 2µg/ml + Rat liver tissue
Secondary
Goat polyclonal to rabbit IgG at 1/15000 dilution
Predicted band size: 61 kDa
Observed band size: 61 kDa

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA022954HA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA022954HA01HU at dilution of 1:100
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) SUOX Polyclonal antibody
Uniprot No.：

P51687
基因名：

SUOX
別名：

EC 1.8.3.1 antibody; mitochondrial antibody; Sulfite oxidase antibody; Sulfite oxidase mitochondrial antibody; Sulfite oxidase; mitochondrial precursor antibody; Suox antibody; SUOX_HUMAN antibody
宿主：

Rabbit
反應(yīng)種屬：

Human, Rat
免疫原：

Recombinant Human Sulfite oxidase, mitochondrial protein (80-545AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，SUOX Antibody (CSB-PA022954HA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于SUOX Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA022954HB01HU	SUOX Antibody, HRP conjugated	ELISA
FITC	CSB-PA022954HC01HU	SUOX Antibody, FITC conjugated
Biotin	CSB-PA022954HD01HU	SUOX Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

基因功能參考文獻(xiàn)：
1. SUOX is negatively associated with the progression and proliferation of oral squamous cell carcinoma. PMID: 29280012
2. This is the first description of the prenatal neurodevelopment of brain disruption in isolated sulfite oxidase deficiency. PMID: 28629418
3. Novel SUOX mutations were detected in 3 Sulfite oxidase deficiency cases PMID: 27289259
4. Nitrite binds and reduces at the molybdenum site of mammalian sulfite oxidase, which may be allosterically regulated by heme and molybdenum domain interactions, and contributes to the mammalian nitrate-nitrite-NO signaling pathway in human fibroblasts. PMID: 25314640
5. This finding suggests the possibility to use oxygen-reactive SO variants in sulfite detoxification, as the loss of SO activity is causing severe neurodegeneration PMID: 26171830
6. Several mutants of H304 and R309 of SUOX were investigated by steady-state kinetics, laser flash photolysis studies of intramolecular electron transfer (IET), and spectroelectrochemistry. PMID: 24968320
7. SUOX was decreased and AKR1B10 and CD34 were increased with the stepwise progression of hepatocarcinogenesis. PMID: 23665285
8. combined genetic association studies in women from China/Netherlands/United States: Data suggest that an SNP in SUOX locus (rs705702) and SNPs in other proteins are associated with polycystic ovary syndrome across ethnic differences. [META-ANALYSIS] PMID: 24106282
9. effect of mutation of surface residues on the heme domain on intramolecular electron transfer, and steady-state kinetics PMID: 22975842
10. In this study a human sulfite oxidase variant, in which the active site has been modified to alter substrate specificity and activity from sulfite oxidation to nitrate reduction, is compared to chicken sulfite oxidase. PMID: 22263579
11. prepared and purified samples of the wild type and various mutants of human SO that are depleted of chloride. These samples do not exhibit the typical lpH EPR spectrum at low pH but rather exhibit spectra that are characteristic of the blocked species PMID: 20491442
12. Experimental deletions of nonconserved amino acids in the 14-residue interdomain polypeptide tether of sulfite oxidase shorten its length and result in more drastically reduced intramolecular electron transfer rate constants. PMID: 20063894
13. role of conserved tyrosine 343 in intramolecular electron transfer in this enzyme PMID: 12424234
14. Sulfite oxidase gene expression in brain and in other tissues. PMID: 12763039
15. comparison of this structure with other b(5)-type cytochromes reveals distinct structural features present in the sulfite oxidase b(5) domain which promote optimal electron transport between the Moco of sulfite oxidase and the heme of cytochrome c PMID: 12832761
16. To further assess the role of Arg 160 in human SO, intramolecular electron transfer rates between the reduced heme and oxidized molybdenum centers in the wild type, R160Q, and R160K human SO forms were investigated by laser flash photolysis PMID: 14567685
17. the Tyr(343) residue is important for both substrate binding and oxidation of sulfite by sulfite oxidase PMID: 14729666
18. mutation in SUOX gene in sulfite oxidase deficiency PMID: 16140720
19. mutations to charged residues at the equivalent sites most likely cause crucial global or localized structural changes, and expose an alternative docking site that may compete with the Mo domain for docking of the heme PMID: 16229463
20. Analysis of recombinant G473D sulfite oxidase indicated that it is severely impaired both in the ability to bind sulfite and in catalysis, with a second-order rate constant 5 orders of magnitude lower than that of the wild type. PMID: 16475804
21. Magnetic resonance imaging and MR spectroscopy measurements may help differentiate isolated sulfite oxidase deficiency from hypoxic-ischemic condition in patients in whom this diagnosis is not clinically suspected. PMID: 17940249
22. analysis of protein-protein interaction of sulfite oxidase and cytochrome c catalyzing oxidation of sulfite PMID: 18177044
23. EPR study of the Mo(V) center of the pathogenic R160Q mutant confirms the presence of three distinct species whose relative abundances depend upon pH. PMID: 18529001
24. the activity of molybdoenzymes, such as sulfite oxidase, is inhibited by high concentrations of heavy metals in the cell PMID: 18959753
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相關(guān)疾病：

Isolated sulfite oxidase deficiency (ISOD)
亞細(xì)胞定位：

Mitochondrion intermembrane space.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 11460

OMIM: 272300

KEGG: hsa:6821

STRING: 9606.ENSP00000266971

UniGene: Hs.558403

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