STYK1 Antibody
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中文名稱：STYK1兔多克隆抗體
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貨號：CSB-PA792569
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規格：￥1100
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圖片：
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Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A431 cells, Primary antibody: CSB-PA792569(STYK1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
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其他：
產品詳情
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Uniprot No.：
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基因名：STYK1
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別名：STYK1; NOK; Tyrosine-protein kinase STYK1; Novel oncogene with kinase domain; Protein PK-unique; Serine/threonine/tyrosine kinase 1
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthetic peptide of Human STYK1
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 WB 1:500-1:2000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways.
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基因功能參考文獻：
- Overexpression of STYK1 was significantly associated with increased cell proliferation, migratory capability, and invasive capability in vitro, as well as increased volume of tumor, weight of tumor, and number of pulmonary metastasesin hepatocellular carcinoma. PMID: 27628214
- STYK1 plays an important role in glioma development and progression. PMID: 27983928
- Findings show that serine-threonine-tyrosine kinase 1 (NOK) mediates glycolysis and nuclear pyruvate dehydrogenase complex (PDC) associated histone acetylation. PMID: 28410146
- Survival analysis reveals that STYK1 level is an independent prognostic factor for nasopharyngeal carcinoma patients. Our results indicate that STYK1 is a promising therapeutic target in nasopharyngeal carcinoma PMID: 28720063
- Thus, our results reveal a novel tumorigenic function of NOK to mediate the genesis and remodeling of blood and lymphatic vessels during tumor progression. PMID: 27444381
- High STYK1 expression is associated with intrahepatic cholangiocarcinoma. PMID: 27542675
- increased STYK1 protein expression correlates with disease progression and metastasis and may serve as a predictor of poor survival in CRC. PMID: 25884558
- The data indicates that both P203 and V395 residues on NOK are important for NOK mediated mitogenic signaling. PMID: 25961552
- NOK expression increased in renal cell carcinoma and was significantly correlated with TNM stage, Fuhrman grade, poor overall survival, poor disease-free survival, metastasis, and proliferation. PMID: 27012048
- STYK1/NOK is dramatically upregulated in colorectal cancer tissues and could be used as a tumor marker. Furthermore, the high expression of STYK1/NOK is significantly associated with tumor size. PMID: 25169509
- These results suggest that STYK1 is a novel drug resistance factor and could be a predictor of the therapeutic response in acute leukemia. PMID: 25190507
- Our results indicate that NOK expression is of clinical significance and can serve as a prognostic biomarker in non-small cell lung cancer. PMID: 24894011
- SuRTK106/NOK/STYK1 was first identified, classified and shown to have predicted pseudokinase domain. PMID: 12471243
- The expression levels of NOK, p-Akt(Thr308) and p-GSK-3beta(Ser9) were positively correlated in cancerous and non-cancerous breast cell lines. PMID: 23010592
- Taken together, NOK has a strong tendency towards forming aggregates, which may have physiological implications and provide the first evidence that this novel receptor kinase is colocalised with EGFR in endosomes to participate in a post-internalisation step of EGFR. PMID: 22516751
- cloning and characterization; mapped to chromosome 12p13; widely expressed in human tissues PMID: 12841579
- NOK mRNA was highly expressed even at the early clinical stages of the cancer. These results suggest that NOK mRNA might be a new tool to support the diagnosis of lung cancers, irrespective of the clinical stages. PMID: 17298854
- The regulation of STYK1/NOK is achieved independent of ERalpha and suggests further investigation to the relevance of this kinase in breast cancer progression. PMID: 17415682
- results indicate that STYK1/NOK mRNA is widely expressed in the patients with acute leukemia and suggest that inhibition of this molecule could potentially serve as a novel therapeutic target PMID: 19409952
- Overexpression of the potential kinase serine/ threonine/tyrosine kinase 1 (STYK 1) in castration-resistant prostate cancer. PMID: 19664042
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亞細胞定位：Membrane; Single-pass membrane protein.
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蛋白家族：Protein kinase superfamily, Tyr protein kinase family
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組織特異性：Widely expressed. Highly expressed in brain, placenta and prostate. Expressed in tumor cells such as hepatoma cells L-02, cervix carcinoma cells HeLa, ovary cancer cells Ho8910 and chronic myelogenous leukemia cells K-562, but not in other tumor cells suc
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