STOML2 Antibody

說明書

中文名稱：

STOML2兔多克隆抗體
貨號：

CSB-PA022864GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9UJZ1
基因名：

STOML2
別名：

EPB72 like protein 2 antibody; EPB72-like protein 2 antibody; HSPC108 antibody; OTTHUMP00000021320 antibody; Paraprotein target 7 antibody; Paratarg 7 antibody; SLP 2 antibody; SLP-2 antibody; SLP2 antibody; STML2_HUMAN antibody; Stomatin (EPB72) like 2 antibody; Stomatin like 2 antibody; Stomatin like protein 2 antibody; Stomatin like protein 2, mitochondrial antibody; Stomatin-like protein 2 antibody; STOML2 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human STOML2
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC,IF
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation.
基因功能參考文獻：
1. TROP-2, SLP-2 and CD56 were effective diagnostic markers for PTC, especially when they were combined to use. PMID: 29951933
2. Data show that SLP-2 is upregulated by high cisplatin concentrations, leading to increased protein turnover. Overexpression of SLP-2 activates the MEK/ERK signaling pathway, and suppresses the mitochondrial apoptosis pathway, indicating that SLP-2 inhibits apoptosis by activating the MEK/ERK pathway and inhibiting the mitochondrial apoptosis pathway in cervical cancer cells. PMID: 29516570
3. The expression of STOML2, a gene that plays a key role in mitochondrial function and T-cell activation, is associated with both IL-6 signaling and asthma risk. PMID: 26932604
4. results reveal an important role of SLP2 membrane scaffolds for the spatial organization of inner membrane proteases regulating mitochondrial dynamics, quality control, and cell survival. PMID: 27737933
5. Slp2 is involved in endometrial stromal cell proliferation and differentiation during decidualization in mice and humans PMID: 27986413
6. The significant association of SLP-2 overexpression with unfavorable clinicopathological characteristics and BRAFV600E mutation indicates that SLP-2 may have a role in aggressiveness of BRAF-mutated papillary thyroid carcinoma. PMID: 26750533
7. Stomatin-like protein 2 is overexpressed in epithelial ovarian cancer and predicts poor patient survival PMID: 26487491
8. STOML2 was correlated to progression in cervical cancer, and implicated it as a potential predictive factor for the prognosis of cervical cancer. PMID: 25973071
9. Our study showed that STOML-2 was negatively regulated by miR1207-5p in esophageal carcinoma PMID: 25695396
10. SLP-2 was upregulated by TGF-beta1, indicating a possible role of SLP-2 in Papillary thyroid cancer tumorigenesis. PMID: 24190591
11. STOML2 may have a role in progression of gastric adenocarcinoma PMID: 24258357
12. Increased levels of SLP-2 correlate with lymph node metastasis in gastric cancer. PMID: 23371255
13. SLP-2 may play an important role in human GBC tumorigenesis, and SLP-2 might serve as a novel prognostic marker in human GBC. PMID: 23918306
14. Expression of SLP-2 is associated with invasion of esophageal squamous cell carcinoma. PMID: 23667687
15. SLP-2 deficiency in T-lymphocytes is associated with abnormal cardiolipin compartmentalization in mitochondrial membranes, defects associated with altered mitochondrial respiration that is increasingly uncoupled from ATP production. PMID: 23028053
16. [review] Stomatin family member STOML2 is oligomeric; it localizes mostly to membrane domains and has been shown to modulate ion channel activity. PMID: 21501885
17. SLP-2 facilitates the compartmentalization not only of mitochondrial membranes but also of the plasma membrane into functional microdomains. PMID: 22623988
18. investigation of biomarkers for early diagnosis of endometriosis: Data suggest that SLP2, tropomyosin 3, and tropomodulin 3 are autoantigens present in blood of women with endometriosis; immunodominant epitopes were identified. PMID: 22158085
19. SLP-2 and HER2/neu can play a role in lymph node/distant metastases of breast cancers PMID: 22081131
20. We propose that the function of SLP-2 is to recruit prohibitins to cardiolipin to form cardiolipin-enriched microdomains in which electron transport complexes are optimally assembled. PMID: 21746876
21. plasma concentrations of stomatin (EPB72)-like 2 in early-stage colorectal cancer patients were elevated as compared with those of healthy individuals PMID: 21209152
22. The dominant inheritance of hyperphosphorylated paratarg-7 explains cases of familial IgM monoclonal gammopathy of undetermined significance and Waldenstrom macroglobulinemia PMID: 21220746
23. negatively modulates mitochondrial sodium-calcium exchange PMID: 19944461
24. SLP-2 overexpression is associated with tumour distant metastasis and poor prognosis in pulmonary squamous cell carcinoma. PMID: 19839737
25. overexpression of stomatin-like protein 2 is associated with neoplasms PMID: 16533792
26. SLP-2 is a high abundance protein in several tissues and cells and may play an important biological role; this study uses mass spectrometry to analyze its primary structure PMID: 16671055
27. SLP-2 was overexpressed in endometrial adenocarcinoma compared with their normal counterparts. PMID: 17342323
28. High-level SLP-2 expression was associated with decreased overall survival (P = .011) and was more often found in patients with tumors larger than 20 mm, lymph node metastasis, advanced clinical stage, distant metastasis PMID: 17709317
29. SLP-2 is an important player in T cell activation by ensuring sustained TCR signaling PMID: 18641330
30. Familial MGUS and multiple myeloma were associated with a dominant inheritance of hyperphosphorylated paratarg-7 PMID: 19767238
31. Endosymbiotic origin of paraslipin from an alphaprotoebacterial ancestor (SLP-2) PMID: 18267007
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亞細胞定位：

Cell membrane; Peripheral membrane protein. Mitochondrion. Mitochondrion inner membrane; Lipid-anchor. Mitochondrion intermembrane space. Membrane raft. Cytoplasm, cytoskeleton.
蛋白家族：

Band 7/mec-2 family
組織特異性：

Ubiquitously expressed at low levels. Expressed in lymphoid tissues (at protein level).
數據庫鏈接：

HGNC: 14559

OMIM: 608292

KEGG: hsa:30968

STRING: 9606.ENSP00000348886

UniGene: Hs.3439

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