STK38 Antibody

說明書

中文名稱：

STK38兔多克隆抗體
貨號：

CSB-PA614885ESR1HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA614885ESR1HU at dilution of 1:100
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) STK38 Polyclonal antibody
Uniprot No.：

Q15208
基因名：

STK38
別名：

NDR 1 antibody; NDR antibody; Ndr Ser/Thr kinase-like protein antibody; NDR1 antibody; NDR1 protein kinase antibody; Nuclear Dbf2 related kinase 1 antibody; nuclear Dbf2-related 1 antibody; Nuclear Dbf2-related kinase 1 antibody; Nuclear Dbf2-related protein antibody; Serine/threonine protein kinase 38 antibody; Serine/threonine-protein kinase 38 antibody; STK 38 antibody; STK38 antibody; STK38_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Serine/threonine-protein kinase 38 protein (1-200AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2.
基因功能參考文獻：
1. Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop. PMID: 30018336
2. Study provides evidence for an inhibitory role of SOCS2 in TNFalpha induced NF-kappa B activation, identifies NDR1 as a novel substrate of SOCS2, and demonstrates that SOCS2 and TNFalpha induced NF-kappa B signaling are linked through NDR1. PMID: 28216640
3. Data show that STK38 supports Ras-driven transformation through promoting detachment-induced autophagy. PMID: 27283898
4. a novel and intimate link between the protein kinase NDR1 and TGFbeta signaling PMID: 23840619
5. Data establish STK38 as a conserved regulator of autophagy in human cells and flies. PMID: 26387716
6. PLK1-mediated phosphorylation protects the binding of Mob1 to NDR1 and subsequent NDR1 activation PMID: 26057687
7. STK38-mediated phosphorylation of CDC25A at Ser-76 and the subsequent degradation of CDC25A are required to promote DNA damage-induced G2/M checkpoint activation. PMID: 25936524
8. STK38 regulates MYC protein stability and turnover in a kinase activity-dependent manner. STK38 kinase inactivation abrogates apoptosis following B-cell receptor activation, whereas its silencing significantly decreases MYC levels and increases apoptosis. PMID: 23178486
9. cyclin D1 has a role in promoting cell cycle progression by enhancing NDR1/2 kinase activity independent of Cdk4 PMID: 23897809
10. 17-allylamino-17-demethoxygeldanamycin down-regulates STK38, modulating radiosensitivity. PMID: 23886587
11. Findings suggest a function of NDR1, which may regulate NF-kappaB activation by its kinase activity. PMID: 22674419
12. GSK-3beta inhibits full activation of STK38, and STK38 activation is required to prevent cell death in response to oxidative stress PMID: 22142472
13. Findings show a biological role for MICAL-1 in apoptosis and define a novel negative regulatory mechanism of MST-NDR signaling. PMID: 21730291
14. These findings establish a novel MST3-NDR-p21 axis as an important regulator of G(1)/S progression of mammalian cells. PMID: 21262772
15. Data indicate that human MOB2 is a negative regulator of human NDR kinases in biochemical and biological settings. PMID: 20624913
16. NDR1 and NDR2 serine-threonine kinases are regulated by mob proteins PMID: 15067004
17. an insert within the catalytic domain between subdomains VII and VIII is autoinhibitory, and the binding of human MOB1 to the N-terminal domain of NDR induces the release of this autoinhibition. PMID: 15197186
18. The NDR1 and NDR2 kinases were incorporated into HIV-1 particles and were cleaved by the HIV-1 protease. PMID: 15582665
19. In vivo activation of human NDR by membrane-bound hMOBs is dependent on their interaction and occurs solely at the membrane. PMID: 16135814
20. These data indicate that NDR-driven centrosome duplication requires Cdk2 activity and that Cdk2-induced centrosome amplification is affected upon reduction of NDR activity. PMID: 17317633
21. phosphorylation of MOB1 at Thr74 by MST2 is essential to make a complex of MOB1, MST2 and NDR1, and to fully activate NDR1 PMID: 18362890
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亞細胞定位：

Nucleus. Cytoplasm.
蛋白家族：

Protein kinase superfamily, AGC Ser/Thr protein kinase family
組織特異性：

Ubiquitously expressed with highest levels observed in peripheral blood leukocytes.
數據庫鏈接：

HGNC: 17847

OMIM: 606964

KEGG: hsa:11329

STRING: 9606.ENSP00000229812

UniGene: Hs.409578

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