STK26 Antibody

說明書

中文名稱：

STK26兔多克隆抗體
貨號：

CSB-PA958497
規格：

￥1100
圖片：
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human fetal brain tissue, 293T cells, Hela cells, Primary antibody: CSB-PA958497(STK26 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
其他：

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靶點詳情

產品詳情

Uniprot No.：

Q9P289
基因名：

STK26
別名：

2610018G03Rik antibody; EC 2.7.11.1 antibody; Mammalian Ste20 like protein kinase 4 antibody; Mammalian STE20-like protein kinase 4 antibody; Mammalian sterile 20 like 4 antibody; MASK antibody; MST 4 antibody; MST-4 antibody; MST3 and SOK1 related kinase antibody; Mst3 and SOK1-related kinase antibody; Mst4 antibody; MST4_HUMAN antibody; RGD1563568 antibody; RP23-245F8.1 antibody; RP6 213H19.1 antibody; Serine/threonine protein kinase 26 antibody; Serine/threonine protein kinase MASK antibody; Serine/threonine protein kinase MST 4 antibody; Serine/threonine protein kinase MST4 antibody; Serine/threonine-protein kinase MASK antibody; Serine/threonine-protein kinase MST4 antibody; STE20 like kinase MST 4 antibody; STE20 like kinase MST4 antibody; STE20-like kinase MST4 antibody; STK26 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthetic peptide of Human STK26
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Mediator of cell growth. Modulates apoptosis. In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation.
基因功能參考文獻：
1. Our work describes an MST4-ATG4B signaling axis that influences glioblastoma autophagy and malignancy PMID: 29232556
2. Low MST-4 expression is associated with Graves' disease. PMID: 28219358
3. these data identify the MST4 kinase as a novel candidate to mediate human pituitary tumorigenesis in a hypoxic environment and position it as a potential therapeutic target. PMID: 25650755
4. Our results suggest that MST4, STK25 and PDCD10 are upregulated in prostate cancer and may play roles in prostate tumorigenesis. MST4 may be a helpful marker for identifying prostate cancer. PMID: 25550858
5. Findings reveal a mechanism by which TRAF6 is regulated and highlight a role for MST4 in limiting inflammatory responses. PMID: 25642822
6. This study describes the key role of MST4 in facilitating the epithelial-mesenchymal transition process in hepatocellular carcinoma PMID: 24859810
7. Mutation of this residue was sufficient to switch the phosphorylation site preference for multiple kinases, including the serine-specific kinase PAK4 and the threonine-specific kinase MST4. PMID: 24374310
8. CCM3 forms a stable complex with MST4 in vivo to promote cell proliferation and migration synergistically in a manner dependent on MST4 kinase activity. PMID: 23541896
9. In this review, the germinal center kinase III subfamily of mammalian Ste20 (sterile 20)-like group of serine/threonine protein kinases comprises Ste20-like/oxidant-stress-response kinase 1, MST3 mammalian Ste20-like kinase 3 and MST4. PMID: 23889253
10. crystal of the CCM3-MST4 C-terminal domain complex belonged to space group P4(1)2(1)2 or P4(3)2(1)2, with unit-cell parameters a = 69.10, b = 69.10, c = 117.57 A PMID: 22750858
11. cloning of a germinal center iii kinase that induces apoptosis PMID: 11741893
12. MST4 expression in prostate carcinoma tumor samples & cell lines correlated with tumorigenicity & AR status. Overexpression induced anchorage-independent growth & tumorigenesis.It may have a role in the signal transduction in prostate cancer progression. PMID: 12810671
13. Results show that PDCD10 modulation of ERK signaling is mediated by MST4, and that PDCD10 may be a regulatory adaptor necessary for MST4 function, suggesting a link between cerebral cavernous malformation and the ERK-MAPK cascade via PDCD10/MST4. PMID: 17360971
14. These data define a brush border induction pathway downstream of the Lkb1/Strad/Mo25 polarization complex, yet separate from other polarity events. PMID: 19386264
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亞細胞定位：

Cytoplasm. Golgi apparatus.
蛋白家族：

Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
數據庫鏈接：

HGNC: 18174

OMIM: 300547

KEGG: hsa:51765

STRING: 9606.ENSP00000377867

UniGene: Hs.444247

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