STARD13 Antibody, Biotin conjugated
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中文名稱：STARD13兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA896714LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) STARD13 Polyclonal antibody
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Uniprot No.：
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基因名：STARD13
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別名：46H23.2 antibody; ARHGAP37 antibody; Deleted in liver cancer 2 protein antibody; Deleted in liver cancer protein 2 antibody; DLC-2 antibody; DLC2 antibody; GT650 antibody; Rho GTPase activating protein on chromosome 13q12 antibody; Rho GTPase-activating protein antibody; STA13 antibody; STA13_HUMAN antibody; StAR related lipid transfer (START) domain containing 13 antibody; StAR-related lipid transfer protein 13 antibody; StARD13 antibody; START domain-containing protein 13 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human StAR-related lipid transfer protein 13 protein (516-679AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.
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基因功能參考文獻：
- Study elucidated StarD13 messenger RNA as a Competitive endogenous messenger RNA (ceRNA) in regulating migration and invasion of breast cancer cells. MicroRNA-125b was identified to induce metastasis of MCF-7 cells and bind with both StarD13 3'UTR and TP53INP1 3'UTR. Therefore, a ceRNA interaction between StarD13 and TP53INP1 mediated by competitively binding to miR-125b was indicated. PMID: 29146309
- Low STARD13 expression is associated with metastasis of breast cancer. PMID: 26985770
- miR-125b functions as an oncogene in gastric cancer and represents a new potential therapeutic target for gastric cancer. PMID: 27220320
- The tumor suppressor DLC2 and Kif1B are central components of a signaling network that guides spindle positioning, cell-cell adhesion and mitotic fidelity. PMID: 25518808
- Dimerization of DLC2 was required for its interaction with GKAP, which, in turn, potentiated GKAP self-association. PMID: 24938595
- Study describes STARD13 as a tumor suppressor playing a positive role in cancer motility. PMID: 24627003
- The present study further describes the role of StarD13 as a tumor suppressor as well as a Rho GAP. PMID: 24253896
- Importance of the regulation of RhoA activity in focal adhesions of astrocytoma cells and StarD13 is a GAP playing a major role in this process. PMID: 24333506
- In the present review, we discuss the family of RhoGTPases, their regulation and their RhoGAPs, focusing mainly on STARD13. [review] PMID: 23316797
- RhoGAP protein Stard13 is an essential regulator of pancreas tissue architecture in the mammalian embryo; Stard13 acts by regulating Rho signalling spatially and temporally during pancreas development. PMID: 23175628
- Authors detected an increase in p-ERK in StarD13 knockdown cells, uncovering a potential link between Rho GTPases and ERK activation. PMID: 22614672
- role of miR-125b in pro-metastasis by targeting STARD13 PMID: 22693547
- DLC2 inhibits the activity of Raf-1-ERK1/2-p70S6K via its RhoGAP function, resulting in the suppression of cell growth. PMID: 20629949
- has GAP activity specific for RhoA and Cdc42; inhibits the Rho mediated assembly of actin stress fibers in cultured cells and is underexpressed in hepatocellular carcinoma tissues PMID: 12531887
- underexpression is associated with poor prognosis in patients with hepatocellular carcinoma PMID: 18651974
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亞細胞定位：Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet.
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組織特異性：Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines.
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數據庫鏈接：
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