STAMBP Antibody

中文名稱：

STAMBP兔多克隆抗體
貨號：

CSB-PA022794HA01HU
規格：

￥440
圖片：
Western blot
All lanes: STAMBP antibody at 12µg/ml
Lane 1: Jurkat whole cell lysate
Lane 2: Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 49, 40 kDa
Observed band size: 49 kDa

Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA022794HA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA022794HA01HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) STAMBP Polyclonal antibody
Uniprot No.：

O95630
基因名：

STAMBP
別名：

AMSH antibody; Associated molecule with the SH3 domain of STAM antibody; Endosome associated ubiquitin isopeptidase antibody; Endosome-associated ubiquitin isopeptidase antibody; MGC126516 antibody; MGC126518 antibody; MICCAP antibody; STABP_HUMAN antibody; STAM binding protein antibody; STAM-binding protein antibody; Stambp antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human STAM-binding protein (1-424AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，STAMBP Antibody (CSB-PA022794HA01HU)，的標記方式是Non-conjugated。對于STAMBP Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA022794HB01HU	STAMBP Antibody, HRP conjugated	ELISA
FITC	CSB-PA022794HC01HU	STAMBP Antibody, FITC conjugated
Biotin	CSB-PA022794HD01HU	STAMBP Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.
基因功能參考文獻：
1. Contrary to previously reported STAMBP mutations, the Ser236Phe mutation did not lead to constitutive activation of the PI3K-AKT-mTOR pathway in patient-derived LCLs, as indicated by the expression of phosphorylated S6 ribosomal protein, suggesting that it is not the major pathomechanism underlying the disorder in this patient. PMID: 29907875
2. Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity. PMID: 28492230
3. Two siblings with classic features of MIC-CAP syndrome that harbor a novel predicted splice mutation in STAMBP PMID: 25692795
4. associated molecule with the SH3 domain of STAM-mediated deubiquitination of connexin 43 protects Gap junctions from degradation PMID: 25070368
5. Recognition of the proximal ubiquitin is imperative for the linkage specificity and catalytic efficiency of AMSH. PMID: 24151880
6. Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly-capillary malformation syndrome. PMID: 23542699
7. AMSH efficiently removes ubiquitin from the activated EGFR. PMID: 22800866
8. tight coupling of ESCRT-III CHMP3 and AMSH functions and provide insight into the regulation of ESCRT-III PMID: 21827950
9. Studies indicate that USP8/Ubpy and AMSH interact with ESCRT components to modulate the ubiquitination status of receptors and relevant sorting proteins. PMID: 21448666
10. AMSH interacts with ESCRT-0 to regulate the stability and trafficking of CXCR4. PMID: 20159979
11. AMSH is a deubiquitinating enzyme with functions at the endosome to oppose ubiquitin-dependent receptor sorting PMID: 15314065
12. The cellular functions of UBPY are complex but clearly distinct from those of the Lys-63-ubiquitin-specific protease, AMSH, with which it shares a binding site on the SH3 domain of STAM PMID: 16520378
13. AMSH and AMSH-LP are anchored on the early endosomal membrane via interaction with the clathrin coat PMID: 16716190
14. AMSH has a role in the deubiquitination of the endosomal cargo preceding lysosomal degradation PMID: 16760479
15. AMSH, which has been recently characterized as a regulator of the endosomal sorting of epidermal growth factor receptor, represents a novel modulator of CaR signaling. PMID: 16854379
16. both the deubiquitination enzyme activity of AMSH and its CHMP3-binding ability are required to clear ubiquitinated cargo from endosomes PMID: 17159328
17. Endosomal AMSH (STAMBP) is a functional component of the multivesicular body pathway. PMID: 17261583
18. UBPY MIT domain and another ubiquitin isopeptidase, AMSH, reveals common interactions with CHMP1A and CHMP1B but a distinct selectivity of AMSH for CHMP3/VPS24, a core subunit of the ESCRT-III complex, and UBPY for CHMP7. PMID: 17711858
19. crystal structures of the human AMSH-LP DUB domain alone and in complex with a Lys 63-linked di-ubiquitin at 1.2 A and 1.6 A resolutions, respectively PMID: 18758443
20. Data suggest that AMSH and UBPY are essential for trafficking and down-regulation of PAR(2) but not for regulating PAR(2) dissociation from beta-arrestin2 or PAR(2)-mediated ERK2 activation. PMID: 19684015
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相關疾病：

Microcephaly-capillary malformation syndrome (MICCAP)
亞細胞定位：

Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Early endosome.
蛋白家族：

Peptidase M67C family
組織特異性：

Ubiquitously expressed.
數據庫鏈接：

HGNC: 16950

OMIM: 606247

KEGG: hsa:10617

STRING: 9606.ENSP00000344742

UniGene: Hs.469018

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