STAM Antibody
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中文名稱：STAM兔多克隆抗體
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貨號：CSB-PA022792GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：DKFZp686J2352 antibody; HSE1 homolog antibody; OTTHUMP00000019237 antibody; Signal transducing adapter molecule 1 antibody; signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 antibody; STAM 1 antibody; STAM antibody; STAM-1 antibody; STAM1_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human STAM
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
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基因功能參考文獻：
- The VHS domain of STAM1 directs AMSH to cleave longer Lys63-linked ubiquitin chains PMID: 26601948
- Differential expression of the transcripts STAM connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes. PMID: 25884766
- ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation. PMID: 25296754
- STAM proteins function in a multivalent complex that sorts ubiquitinated proteins into the multivesicular body pathway. PMID: 12551915
- Interaction of TIMM8a with STAM1. PMID: 12745081
- Data suggested that association with hepatocyte growth factor-regulated tyrosine kinase substrate is a prerequisite for STAM1 function in early endosome. PMID: 15113837
- Hrs is a master molecule that controls in part the degradation of STAM1 and the accumulation of ubiquitinated proteins PMID: 15640163
- Analysis with phospho-specific antibodies indicates that 3 kinases generate a signal-specific, combinatorial phosphorylation profile of the Hrs-STAM complex, with the potential of diversifying tyrosine kinase receptor signalling through a common element. PMID: 15828871
- The cellular functions of UBPY are complex but clearly distinct from those of the Lys-63-ubiquitin-specific protease, AMSH, with which it shares a binding site on the SH3 domain of STAM PMID: 16520378
- STAMs function prominently in endoplasmic reticulum-to-Golgi trafficking, most likely through direct interactions with the coat protein II complex PMID: 19054391
- A novel ubiquitin binding site and the manner of ubiquitin recognition of the STAM1 VHS domain were proposed. PMID: 19111546
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亞細胞定位：Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.
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蛋白家族：STAM family
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組織特異性：Ubiquitously expressed.
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數據庫鏈接：
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