STAB2 Antibody
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中文名稱：STAB2兔多克隆抗體
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貨號：CSB-PA851979ESR1HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA851979ESR1HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) STAB2 Polyclonal antibody
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Uniprot No.：
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基因名：STAB2
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別名：190 kDa form stabilin-2 antibody; 190 kDa hyaluronan receptor for endocytosis antibody; EGF-like antibody; FAS1 EGF-like and X-link domain-containing adhesion molecule 2 antibody; Fasciclin antibody; FEEL-2 antibody; FEEL2 antibody; FELL antibody; FEX2 antibody; HARE antibody; Hyaluronan receptor for endocytosis antibody; laminin-type EGF-like and link domain-containing scavenger receptor 2 antibody; link domain-containing scavenger receptor 2 antibody; STAB-2 antibody; Stab2 antibody; STAB2_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Stabilin-2 protein (1550-1850AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalization as well as HA and CS.
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基因功能參考文獻：
- Structural Determinants for the Interactions of Chemically Modified Nucleic Acids with the Stabilin-2 Clearance Receptor. PMID: 29589907
- Data show that the hyaluronan receptor for endocytosis (HARE) NPLY2519 motif is necessary for both extracellular signal-regulated kinases ERK1/2 and NF-kappa B (NF-kappaB)signaling and that Tyr2519 is critical for these functions. PMID: 27100626
- Stabilin-2 can play a critical role in the first entrapping step of LN metastasis through homotypic interaction with the lymphatic endothelium and appears to be a tumor biomarker predicting for LN metastasis in patients with solid tumors PMID: 27919991
- HARE/Stabilin-2 splice variants are expressed in bone marrow, lymph node, and spleen PMID: 25446080
- a Link domain complex N-glycan is required specifically for HARE.hyaluronic acid-mediated activation of ERK1/2 and NF-kappaB-mediated gene expression PMID: 24942734
- Loss of Stabilin-2 expression in peri-tumourous transdifferentiated liver endothelial cells correlates with increased survival by preventing endothelial-tumour cell adhesive interactions and microvascular invasion. PMID: 23870052
- HARE may be part of a systemic tissue-stress sensor feedback system that responds to abnormal tissue turnover or damage as a danger signal PMID: 24247245
- stabilin-2 acts as a receptor for necrotic cell clearance. PMID: 23416077
- Hyaluronan binding to HARE mediates NF-kappaB-activated gene expression in a dose-dependent manner. PMID: 23530033
- knockdown of endogenous alphavbeta5 expression or treatment with a function-blocking alphavbeta5 antibody significantly decreased stabilin-2-mediated phagocytosis in the absence of soluble factors PMID: 22566688
- Ligament Flavum (LF) hypertrophy is accompanied by increased CD44 and CD44v5 expression. CD44v6 expression is not enhanced in LF hypertrophy. PMID: 22052472
- The results indicate that Link domain N-glycans stabilize interactions that facilitate HA binding to HARE. PMID: 20466649
- code for homologous transmembrane proteins featuring seven fasciclin-like adhesion domains, 18-20 epidermal-growth-factor domains, one X-link domain and three to six B-(X(7))-B hyaluronan-binding motifs PMID: 11829752
- amino acid sequence of 190-kDa protein composed of 1416 amino acids and alignment with rat sequence PMID: 12626425
- HARE has a role in endocytosis and species-specific glycosaminoglycan affinity PMID: 15208308
- A majority of HARE isoform is intracellular, within the endocytic system, suggesting transient surface residency typical of an active endocytic recycling receptor. PMID: 17145755
- study provides evidence that stabilin-2 is a novel phosphatidylserine receptor, which performs a key function in the rapid clearance of cell corpses PMID: 17962816
- GULP is a likely downstream molecule in the stabilin-2-mediated signaling pathway and plays an important role in stabilin-2-mediated phagocytosis PMID: 18230608
- when HARE binds HA, that leads to activation of ERK1/2, important mediators of intracellular signal transduction. PMID: 18387958
- HARE in the sinusoidal endothelial cells of lymph nodes and liver likely mediates the efficient systemic clearance of Hep and many different Hep-binding protein complexes from the lymphatic and vascular c PMID: 18434317
- HARE binds to hyaluronan and heparin simultaneously PMID: 18499864
- Thymosin beta4 is a downstream molecule of stabilin-2 that plays a role in stabilin-2-mediated cell corpse clearance. PMID: 18519035
- although NPLY may be the most important motif, it functions together with two other endocytic motifs; thus three signal sequences (YSYFRI, FQHF, and NPLY) provide redundancy to mediate coated pit targeting and endocytosis of HARE PMID: 18539600
- Epidermal growth factor (EGF)-like domain repeats (EGFrp) in stabilin-2 can directly and specifically recognize phosphatidylserine. PMID: 18573870
- Both unfractionated heparin (UFH) and low-molecular-weight heparin (LMWH) are cleared by HARE/Stab2. The differences in the affinities of HARE binding to LMWH and UFH likely explain the longer in vivo circulating half-life of LMWH compared with UFH. PMID: 19359419
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亞細胞定位：Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Only a small amount appears to be present at the cell surface (PubMed:17145755).
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組織特異性：Highly expressed in sinusoidal endothelial cells of liver, spleen and lymph nodes. Also expressed in non SEC-cells such as HMDMs (monocyte-derivedmacrophages), HAMs (T-cell leukemia virus type 1-associated myelopathy), and several macrophage cell line.
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