STAB1 Antibody

說明書

中文名稱：

STAB1兔多克隆抗體
貨號：

CSB-PA981609
規(guī)格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA981609(STAB1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
其他：

產品詳情
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靶點詳情

產品詳情

Uniprot No.：

Q9NY15
基因名：

STAB1
別名：

CLEVER 1 antibody; Common lymphatic endothelial and vascular endothelial receptor 1 antibody; EGF-like antibody; Fasciclin antibody; Fasciclin EGF like laminin type EGF like and link domain containing scavenger receptor 1 antibody; fasciclin egf-like antibody; FEEL 1 antibody; FEEL-1 antibody; FELE 1 antibody; FEX1 antibody; KIAA0246 antibody; laminin-type EGF-like and link domain-containing scavenger receptor 1 antibody; MS 1 antigen antibody; MS-1 antigen antibody; STAB 1 antibody; Stab1 antibody; STAB1_HUMAN antibody; Stabilin-1 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthetic peptide of Human STAB1
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system.
基因功能參考文獻：
1. Satb1 promotes osteoclastogenesis by recruiting CREB-binding protein to upregulate miR-223 expression in chronic kidney disease-mineral and bone disorder PMID: 29442043
2. Systemic rAAV-DCN in neuroblastoma-grafted nude mice inhibited stabilin-1. PMID: 28631095
3. Results suggest stabilin-1 mediated silent clearance of extracellular tumor growth-inhibiting factors as a mechanism of stabilin-1 induced tumor growth. PMID: 27105498
4. These data define stabilin-1 as a new immunosuppressive molecule and suggest that stabilin-1(high) monocytes may dampen proinflammatory reactions in vivo. PMID: 26608916
5. The present findings suggest that STAB1 is a new and highly promising candidate gene in this region. The combining of gene expression and GWAS data may provide valuable insights into the biological mechanisms of BD. PMID: 25136889
6. Genes within recently identified loci associated with waist-hip ratio (WHR) exhibit fat depot-specific mRNA expression, which correlates with obesity-related traits. Adipose tissue (AT) mRNA expression of 6 genes (TBX15/WARS2, STAB1, PIGC, ZNRF3, GRB14 PMID: 23670221
7. The associations between CLEVER-1 expression on endothelial vessels and macrophage/leukocyte infiltration is suggestive of its regulation by inflammatory conditions in breast cancer, most likely by macrophage-associated cytokines. PMID: 21483103
8. macrophage stabilin-1/CLEVER-1 can potentially regulate leukocyte migration and scavenging during the development of the placenta and fetus PMID: 21480214
9. Studies identified a binding site on SPARC for stabilin-1 by a solid-state peptide array coupled with a modified enzyme-linked immunosorbent assay. PMID: 21308731
10. CLEVER-1/stabilin-1 can support lymphocyte transendothelial migration; it also may provide an organ-specific signal for regulatory T cell recruitment to the inflamed liver and to hepatocellular carcinoma. PMID: 21368224
11. Studies shoe that understanding stabilin-1 behavior in complex biological systems and would open perspectives for therapeutic targeting of stabilin-1 pathways in chronic inflammation. PMID: 20953554
12. these results indicate that GULP functions as an adaptor protein for stabilin-1-mediated phagocytosis. PMID: 20599701
13. role in endocytic clearance and secretion in macrophages; review PMID: 19457577
14. code for homologous transmembrane proteins featuring seven fasciclin-like adhesion domains, 18-20 epidermal-growth-factor domains, one X-link domain and three to six B-(X(7))-B hyaluronan-binding motifs PMID: 11829752
15. FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities. PMID: 12077138
16. This and FEEL-2 are endocytic receptors for advanced glycation end products. PMID: 12473645
17. CLEVER-1 also known as stabilin-1 or FEEL-1) is a large multifunctional glycoprotein implicated in scavenging, angiogenesis, cell adhesion and angiogenesis PMID: 15297319
18. role for stabilin-1 as a rapidly recycling scavenger receptor PMID: 15345716
19. stabilin-1 may function in endocytic and secretory processes of human macrophages. PMID: 15345724
20. Stabilin-1 internalizes and targets secreted protein acidic and rich in cysteine (SPARC) to an endosomal pathway in stably transfected Chinese hamster ovary cells. PMID: 16670288
21. Stabilin-1 mediates internalization and endosomal sorting of placental lactogen. PMID: 18292525
22. Stabilin-1, found on alternatively activated macrophages, is a phagocytic receptor mediating the clearance of apoptotic cells in a phosphatidylserine-dependent manner. PMID: 19726632
23. The novel GGA-binding site EDDADDD is essential for stabilin-1-mediated intracellular sorting but is not required for endocytosis. PMID: 19752197
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亞細胞定位：

Membrane; Single-pass type I membrane protein.
組織特異性：

High levels found in spleen, lymph node, liver and placenta. Also expressed in endothelial cells.
數據庫鏈接：

HGNC: 18628

OMIM: 608560

KEGG: hsa:23166

STRING: 9606.ENSP00000312946

UniGene: Hs.301989

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