SRGN Antibody

中文名稱：

SRGN兔多克隆抗體
貨號：

CSB-PA022664EA01HU
規格：

￥440
圖片：
IHC image of CSB-PA022664EA01HU diluted at 1:400 and staining in paraffin-embedded human spleen tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SRGN Polyclonal antibody
Uniprot No.：

P10124
基因名：

SRGN
別名：

Chondroitin sulfate proteoglycan core protein antibody; Cytolytic granule proteoglycan core protein antibody; FLJ12930 antibody; gp600 antibody; Hematopoetic proteoglycan core protein antibody; Mastocytoma proteoglycan core protein antibody; MGC9289 antibody; OTTHUMP00000019716 antibody; P.PG antibody; PG19 core protein antibody; Pgsg antibody; Platelet proteoglycan core protein antibody; platelet proteoglycan protein core antibody; PLATELET PROTEOGLYCAN PROTEIN CORE; PPG antibody; PPG antibody; PRG antibody; PRG1 antibody; PROTEOGLYCAN 1 antibody; proteoglycan 1; secretory granule antibody; Proteoglycan 10K core protein antibody; Proteoglycan peptide core protein antibody; PROTEOGLYCAN PROTEIN CORE FOR MAST CELL SECRETORY GRANULE antibody; secretory granule proteoglycan 1 antibody; Secretory granule proteoglycan core peptide antibody; Secretory granule proteoglycan core protein antibody; Serglycin antibody; serglycin proteoglycan antibody; Sgc antibody; Srgn antibody; SRGN_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Serglycin protein (28-154AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，SRGN Antibody (CSB-PA022664EA01HU)，的標記方式是Non-conjugated。對于SRGN Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA022664EB01HU	SRGN Antibody, HRP conjugated	ELISA
FITC	CSB-PA022664EC01HU	SRGN Antibody, FITC conjugated
Biotin	CSB-PA022664ED01HU	SRGN Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.
基因功能參考文獻：
1. SRGN overexpression promoted colorectal cancer cell migration and invasion and SRGN was physically binding to a hypoxia response element in its promoter region. PMID: 30121667
2. SRGN secreted by tumor cells and stromal components in the TME promotes malignant phenotypes through interacting with tumor cell receptor CD44 PMID: 27819672
3. Extracellular spce serglycin upregulated CD44 receptor expression to maintain nasopharyngeal carcinoma stemness by interacting with CD44 and activating the MAPK/beta-catenin pathway. PMID: 27809309
4. SRGN expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
5. Patients with NPC with tumors showing strong tumor intensity and low infiltrated percentage of tumor-infiltrated lymphocytes with serglycin may be at high risk for distant metastases. PMID: 24995621
6. The elevated levels of serglycin in aggressive cancer and stromal cells may suggest a key role for serglycin in disease progression PMID: 26581653
7. These results suggest functions for serglycin in endothelial cells trough interactions with partner molecules, in biological processes with relevance for diabetic complications, cardiovascular disease and cancer development. PMID: 26694746
8. These results suggest that different signaling pathways are involved in regulating secretion of serglycin and partner molecules in activated endothelial cells. PMID: 24513305
9. The reduced expression of SRGN was accompanied by elevated levels of E-cadherin. PMID: 23996242
10. These studies provide direct evidence for a critical role for serglycin in MM pathogenesis and show that targeting serglycin may provide a novel therapeutic approach for MM. PMID: 24403068
11. These results suggest that human epicardial adipose tissue (EAT) has strong inflammatory properties in patients with coronary artery disease and provide novel evidence that serglycin is an adipocytokine highly expressed in EAT. PMID: 23376071
12. Cell-surface SRGN promotes the adhesion of myeloma cells to collagen type I. PMID: 23387827
13. This review covers recent studies on the involvement of serglycin in various pathological conditions, as well as its roles in immunity, hemostasis, cell growth, apoptosis, and reproduction. PMID: 22807344
14. Human granulocyte precursors transfected with siRNA against serglycin displayed reduced capability to retain fully processed HNP-1. PMID: 21849484
15. Serglycin regulates NPC metastasis via autocrine and paracrine routes, and that it serves as an independent prognostic indicator of metastasis-free survival and disease-free survival in NPC patients. PMID: 21289131
16. Serglycin secreted by human multiple myeloma cell lines inhibits both the classical and lectin pathways of complement, without influencing alternative pathway activity. PMID: 21268013
17. Serglycin is a major proteoglycan in polarized human endothelial cells and is implicated in the secretion of the chemokine GROalpha/CXCL1. PMID: 21075844
18. proapoptotic granzyme is exocytosed predominantly as a macromolecular complex with serglycin PMID: 12388539
19. cell- and differentiation-specific alterations in chromatin structure may control serglycin gene expression PMID: 14506241
20. serglycin-bound granzyme B in high-molecular-weight degranulate material from cytotoxic T lymphocytes predominantly followed a dynamin-dependent pathway to kill target cells PMID: 14739229
21. mechanism of delivery is proposed entailing electrostatic transfer of granzyme B from serglycin to cell surface proteins PMID: 15788411
22. Serglycin release is a constitutive process, which may be of fundamental biological importance in the study of multiple myeloma. PMID: 16870619
23. Serglycin is of importance for secretory processes in human monocytes. PMID: 17909965
24. Mutations in SRGN is not associated with familial hemophagocytic lymphohistiocytosis PMID: 18000860
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亞細胞定位：

Cytoplasmic granule. Cytolytic granule. Secreted, extracellular space. Golgi apparatus.
蛋白家族：

Serglycin family
數據庫鏈接：

HGNC: 9361

OMIM: 177040

KEGG: hsa:5552

STRING: 9606.ENSP00000242465

UniGene: Hs.1908

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