SRFBP1 Antibody, Biotin conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SRFBP1 Polyclonal antibody
Uniprot No.：

Q8NEF9
基因名：

SRFBP1
別名：

p49 / STRAP antibody; p49 antibody; p49/STRAP antibody; serum response factor binding protein 1 antibody; Serum response factor-binding protein 1 antibody; SRF dependent transcription regulation associated protein antibody; SRF-dependent transcription regulation-associated protein antibody; SRFB1_HUMAN antibody; SRFBP 1 antibody; SRFBP1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Serum response factor-binding protein 1 protein (201-429AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.
基因功能參考文獻：
1. P49/STRAP expression was increased in the old versus young adult mouse hearts and also increased with advancing population doubling levels in cultured human umbilical vein endothelial cells. The increased expression of p49/STRAP in late life may alter the status of histone acetylation and impact mitochondrial dynamics and thereby reduce mitochondrial function and cardiac performance during mammalian senescence. PMID: 27337995
2. SRFBP1 is an HCV-specific, pan-genotypic host entry factor. PMID: 26212323
3. p49/STRAP may be an important SRF cofactor in the transcriptional regulation of mammalian cardiac muscle genes throughout the life span PMID: 15492011
4. p49/STRAP plays a role in the regulation of intracellular processes such as cardiac cellular metabolism, gene expression, and possibly aging. PMID: 18230186
5. p49/STRAP can be considered a bona fide co-chaperone of Hsp70. PMID: 19751705
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亞細胞定位：

Cytoplasm, perinuclear region.
組織特異性：

Abundantly expressed in heart and skeletal muscle, and at much lower levels in brain and lung.
數據庫鏈接：

HGNC: 26333

OMIM: 610479

KEGG: hsa:153443

STRING: 9606.ENSP00000341324

UniGene: Hs.107622

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